ArrayExpress Uploaderarrayexpress_sidhumanA375 melanoma cell-linecontrolwild typeA375 melanoma cell-linecontrolwild typeA375 melanoma cell-linecontrolwild typeA375 melanoma cell-linecontrolwild typeA375 melanoma cell-linecontrolWnt-1 overexpressingA375 melanoma cell-linecontrolWnt-1 overexpressingA375 melanoma cell-linecontrolWnt-1 overexpressingA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)wild typeA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)wild typeA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)wild typeA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)wild typeA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)Wnt-1 overexpressingA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)Wnt-1 overexpressingA375 melanoma cell-lineanimals were fed with CsA (50mg/kg/day)Wnt-1 overexpressingM24met melanoma cell-linecontrolwild typeM24met melanoma cell-linecontrolwild typeM24met melanoma cell-linecontrolwild typeM24met melanoma cell-linecontrolwild typeM24met melanoma cell-linecontrolwild typeM24met melanoma cell-linecontrolWnt-1 overexpressingM24met melanoma cell-linecontrolWnt-1 overexpressingM24met melanoma cell-linecontrolWnt-1 overexpressingM24met melanoma cell-linecontrolWnt-1 overexpressingM24met melanoma cell-linecontrolWnt-1 overexpressing392704We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and...22572818E-GEOD-26656/profile/8773/arrayexpressuploader324celllymphmelanomascidDec.12, 2014FalseE-GEOD-26656_A-AFFY-44gene-expression-profiles-of-wnt-1-overexpressing-mGene expression profiles of Wnt-1 overexpressing melanomaSep.15, 2014We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and non-canonical targets genes in response to Wnt-1 as compared with controls. In regard to lymphangiogenic factors, the amount of VEGF-C was the single best marker to correlate with the amount of lymph-angiogenesis. mRNA expression array of human melanoma orthotopically grown in SCID mice. Comparison includes mRNA expression profile of two melanoma cell-lines (A375 and M24met) stably overexpressing control vector or Wnt-1 treated with or without CsA. Comparison #1 comprised Wnt-1 versus control in A375 and M24met melanoma, respectively. Comparison #2 comprised Wnt-1 + Cyclosporine A (CsA) versus Wnt-1 without CsA.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26656http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26656/samples/