{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM656286": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656286": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656286": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656286": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656290": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656290": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656290": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656293": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "wild type"}}, {"GSM656293": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "wild type"}}, {"GSM656293": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "wild type"}}, {"GSM656293": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "wild type"}}, {"GSM656297": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656297": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656297": {"CELL LINE": "A375 melanoma cell-line", "TREATMENT": "animals were fed with CsA (50mg/kg/day)", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656300": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656300": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656300": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656300": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656300": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "wild type"}}, {"GSM656305": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656305": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656305": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656305": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}, {"GSM656305": {"CELL LINE": "M24met melanoma cell-line", "TREATMENT": "control", "VARIATION": "Wnt-1 overexpressing"}}], "id": 3927, "pop_total": 0, "platform": 4, "summary_wrapped": "We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and...", "pubmed_id": 22572818, "geo_gse_id": "E-GEOD-26656", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 24, "tags": ["cell", "lymph", "melanoma", "scid"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-26656_A-AFFY-44", "slug": "gene-expression-profiles-of-wnt-1-overexpressing-m", "geo_gds_id": "", "name": "Gene expression profiles of Wnt-1 overexpressing melanoma", "created": "Sep.15, 2014", "summary": "We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and non-canonical targets genes in response to Wnt-1 as compared with controls. In regard to lymphangiogenic factors, the amount of VEGF-C was the single best marker to correlate with the amount of lymph-angiogenesis. mRNA expression array of human melanoma orthotopically grown in SCID mice. Comparison includes mRNA expression profile of   two melanoma cell-lines (A375 and M24met) stably overexpressing control vector or Wnt-1 treated with or without CsA. Comparison #1 comprised Wnt-1 versus control in A375 and M24met melanoma, respectively. Comparison #2 comprised Wnt-1 + Cyclosporine A (CsA) versus Wnt-1 without CsA.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26656", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26656/samples/"}