{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3924, "factors": [{"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655319": {"IMMUNOTOLERANCE GROUP": "TOL POST"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655319": {"IMMUNOTOLERANCE GROUP": "TOL POST"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655319": {"IMMUNOTOLERANCE GROUP": "TOL POST"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655319": {"IMMUNOTOLERANCE GROUP": "TOL POST"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655319": {"IMMUNOTOLERANCE GROUP": "TOL POST"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655330": {"IMMUNOTOLERANCE GROUP": "Non TOL"}}, {"GSM655318": {"IMMUNOTOLERANCE GROUP": "TOL"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients...", "pubmed_id": 22156196, "geo_gse_id": "E-GEOD-26622", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 24, "tags": ["liver", "organ", "point"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "molecular-characterization-of-liver-allografts-fro", "geo_id_plat": "E-GEOD-26622_A-AFFY-44", "name": "MOLECULAR CHARACTERIZATION OF LIVER ALLOGRAFTS FROM OPERATIONALLY TOLERANT TRANSPLANT RECIPIENTS (Affymetrix)", "created": "Sep.15, 2014", "summary": "In clinical organ transplantation complete cessation of immunosuppressive therapy can be successfully accomplished in selected recipients providing a proof-of-principle that allograft tolerance is attainable in humans. The intra-graft molecular pathways associated with human allograft tolerance, however, have not been comprehensively studied before. In this study we analyzed sequential liver tissue samples collected from liver recipients enrolled in a prospective multicenter immunosuppressive withdrawal clinical trial. Tolerant and non-tolerant recipients differed in the intra-graft expression of genes involved in the regulation of iron homeostasis.These results point to a critical role of iron homeostasis in the regulation of intra-graft alloimmune responses in humans and provide a set of novel biomarkers to conduct drug-weaning trials in liver transplantation. The complete database comprised the expression measurements of 54,675 genes for liver inmunotolerance groups: 9 Tolerant (TOL) 10 Non Tolerant (Non TOL).A subset of 5 tolerant samples  (TOL POST) were taken 1 year after inmunosuppresive therapy.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26622", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26622/samples/"}