ArrayExpress Uploader03920not specified7.3 yearsnot specifiedGlioblastomanot specifiednot specifiednot specifiednot specifiednot specified4 yearsnot specifiedGlioblastomanot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedLGG-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednormal-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednormal-brainstemnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiedPostmortemDIPG11.8NDnot specifiednot specifiednot specifiednot specifiedPostmortemDIPG7.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPretreatment collected postmortemDIPG5.5Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG4.3Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG6.1Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG13.7Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.5Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.2Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.7Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.3Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG3.6Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortem sample matched to pretreatment sample BSG024TDDIPG14.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPretreatmentDIPG14.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG12.3Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.2Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG10.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG3.7Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG8.9Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG13.2Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG15.7Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG6Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG12.5Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG10.2Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG9Glioblastomanot specifiednot specifiednot specifiednot specifiedPostmortemDIPG5.6Glioblastomanot specifiednot specifiednot specifiednot specifiedPretreatmentDIPGnanNDnot specifiednot specifiedarrayexpress_sid4Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to...21931021E-GEOD-26576/profile/8773/arrayexpressuploader837brainstemcellgliomanucleotideoutsidetyrosineDec.12, 2014Falsegenome-wide-analyses-of-diffuse-intrinsic-pontineE-GEOD-26576_A-AFFY-44Genome-wide Analyses of Diffuse Intrinsic Pontine GliomasSep.15, 2014Purpose: More than 90% of children with diffuse intrinsic pontine glioma (DIPG) die within 2 years of diagnosis. There is a dire need to identify therapeutic targets, however lack of patient material for research has limited progress. We evaluated a large cohort of diffuse intrinsic pontine gliomas (DIPGs) to identify recurrent genomic abnormalities and gene expression signatures underlying DIPG. Patients and Methods: We used single nucleotide polymorphism arrays to evaluate genomic copy number imbalances in 43 DIPGs from 40 patients and in 8 low-grade exophytic brainstem gliomas. Gene expression arrays were used to evaluate expression signatures from 27 DIPGs, 6 low-grade exophytic brainstem gliomas and 66 low-grade gliomas arising outside the brainstem. Results: Frequencies of specific large-scale and focal imbalances varied significantly between DIPGs and pediatric glioblastomas outside the brainstem. Focal amplifications of genes within the receptor tyrosine kinase-Ras-PI3-kinase signaling pathway were found in 47% of DIPG, with PDGFRA and MET showing the highest frequency. 30% of DIPG contained focal amplifications of cell-cycle regulatory genes controlling RB phosphorylation, and 21% had concurrent amplification of genes from both pathways. Some tumors showed heterogeneity in amplification patterns. DIPGs showed distinct gene expression signatures relating to developmental processes compared to pediatric glioblastomas arising outside the brainstem, while expression signatures of low-grade exophytic brainstem gliomas were similar to low-grade gliomas outside the brainstem. Copy number analaysis: 43 DIPG samples, 8 Low Grade Gliomas using SNP6.0. Available matched normals are also profiled with SNP6.0. Expression analysis: 29 DIPG samples, 6 Low grade samples Please contact Suzanne Baker at Suzanne.Baker@stjude.org for CEL files and genotype calls.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26576humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26576/samples/