{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3916, "factors": [{"GSM652229": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "3", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "7.3", "NET INSR EXPRESSION BY FACS": "7.61%", "OF NUCLEI)": "11q,trisomy 12, 13q", "FISH-ALL": "11q,trisomy 12, 13q", "MEAN": 13}}, {"GSM652230": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "20", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "6.6", "NET INSR EXPRESSION BY FACS": "6.01%", "OF NUCLEI)": "6q, 11q", "FISH-ALL": "6q, 11q", "MEAN": 22}}, {"GSM65223": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "2", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "9.4", "NET INSR EXPRESSION BY FACS": "7.31%", "OF NUCLEI)": "11q, trisomy 12", "FISH-ALL": "11q, trisomy 12", "MEAN": 87}}, {"GSM652232": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "6", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "9.3", "NET INSR EXPRESSION BY FACS": "3.30%", "OF NUCLEI)": "6q, 11q", "FISH-ALL": "6q, 11q", "MEAN": 32}}, {"GSM652233": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "3", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "5.6", "NET INSR EXPRESSION BY FACS": "24.55%", "OF NUCLEI)": "11q, 13q", "FISH-ALL": "11q, 13q", "MEAN": 1}}, {"GSM652234": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "1", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "5.2", "NET INSR EXPRESSION BY FACS": "40.27%", "OF NUCLEI)": "11q", "FISH-ALL": "11q", "MEAN": 59}}, {"GSM652235": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "2", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "6.1", "NET INSR EXPRESSION BY FACS": "28.59%", "OF NUCLEI)": "13q, 11q", "FISH-ALL": "13q, 11q", "MEAN": 63}}, {"GSM652236": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "2", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "5.10%", "OF NUCLEI)": "11q", "FISH-ALL": "11q", "MEAN": 49}}, {"GSM652237": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "2", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "4.5", "NET INSR EXPRESSION BY FACS": "37.17%", "OF NUCLEI)": "11q, 13q", "FISH-ALL": "11q, 13q", "MEAN": 30}}, {"GSM652238": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "2", "DEL11Q STATUS": "del11q present", "DELTA CTM INSR-GAPD": "13.4", "NET INSR EXPRESSION BY FACS": "2.61%", "OF NUCLEI)": "11q, 13q", "FISH-ALL": "11q, 13q", "MEAN": 7}}, {"GSM652239": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "4.32%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 76}}, {"GSM652240": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "13.3", "NET INSR EXPRESSION BY FACS": "4.36%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 88}}, {"GSM65224": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "1.70%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 89}}, {"GSM652242": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "4.17%", "OF NUCLEI)": "normal", "FISH-ALL": "13q", "MEAN": 91}}, {"GSM652243": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "1", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "12.1", "NET INSR EXPRESSION BY FACS": "5.44%", "OF NUCLEI)": "trisomy 12", "FISH-ALL": "trisomy 12", "MEAN": 56}}, {"GSM652244": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "3.30%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 16}}, {"GSM652245": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "2.64%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 73}}, {"GSM652246": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "absent", "NET INSR EXPRESSION BY FACS": "1.41%", "OF NUCLEI)": "13q", "FISH-ALL": "13q", "MEAN": 39}}, {"GSM652247": {"0 TOTAL SUBCHROMOSOMAL AND CHROMOSOMAL LESIONS": "not specified", "DEL11Q STATUS": "non-del11q", "DELTA CTM INSR-GAPD": "11.9", "NET INSR EXPRESSION BY FACS": "3.31%", "OF NUCLEI)": "normal", "FISH-ALL": "normal", "MEAN": 5}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely...", "pubmed_id": 21307146, "geo_gse_id": "E-GEOD-26526", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 7, "sample_count": 19, "tags": ["cll", "insulin", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "a-pathobiological-role-of-the-insulin-receptor-in", "geo_id_plat": "E-GEOD-26526_A-AFFY-44", "name": "A Pathobiological Role of the Insulin Receptor in CLL.", "created": "Sep.15, 2014", "summary": "Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results:  We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL with del11q.  High INSR mRNA expression in 11q CLL (~10-fold higher mean levels than other genomic categories) was confirmed by Q-PCR in 247 CLL cases. INSR protein measurements in 257 CLL cases through FACS, compared with measurements in normal CD19+ B-cells and monocytes, confirmed that a subset of CLL aberrantly expresses high INSR levels. We have employed integrated genomic profiling approaches upon CLL cases with and without del11q to identify 11q-relevant genes. Included are 10 primary human cases with del11q and 9 cases without del11q", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26526", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26526/samples/"}