BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Expression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes

Dataset: Expression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes

We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone...

Registered by ArrayExpress Uploader
View Dataset

We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone (GH)-deficient state. Using microarray profiles, comparison between h-hepatocytes from h-GH-treated and untreated mice identified 14 GH-up-regulated and four GH-down-regulated genes, including IGF-1, SOCS2, NNMT, IGFLS, P4AH1, SLC16A1, and SRD5A1, and FADS1 and AKR1B10, respectively. The chimeric mice were treated or untreated with h-GH at 2.5 mg/kg b.w. /day for 2 weeks before sacrifice. Hepatocytes or liver tissue were isolated from the mouse livers and their cDNAs were used for microarray analysis.

Species:
human

Samples:
14

Source:
E-GEOD-26224

PubMed:
21303949

Updated:
Jun.29, 2015

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample GENDER OF MICE ORGANISM PART ML AGE OF MICE WK DAYS POST-TRANSPLANTATION DONOR OF HEPATOCYTES
GSM643847 female not specified 16.1 14 72 Caucasian 9-month-old male infant
GSM643848 female not specified 10.4 14 75 Caucasian 9-month-old male infant
GSM643849 female not specified 6 18 101 Caucasian 9-month-old male infant
GSM643850 male not specified 8.1 14 75 Caucasian 9-month-old male infant
GSM64385 female not specified 6.2 14 75 Caucasian 9-month-old male infant
GSM643852 female not specified 5.9 14 75 Caucasian 9-month-old male infant
GSM643853 male Liver tissue 5.3 15 84 African American 6-year-old girl
GSM643854 female Liver tissue 3.7 15 84 African American 6-year-old girl
GSM643855 female Liver tissue 5.9 15 84 African American 6-year-old girl
GSM643856 female Liver tissue 3.5 17 97 African American 6-year-old girl
GSM643857 female Liver tissue 6.5 16 90 African American 6-year-old girl
GSM643858 female Liver tissue 5.2 19 111 African American 6-year-old girl
GSM643859 male White region of liver tissues − 12 − −
GSM643860 male Red region of liver tissues − 12 − −

Tags

  • hepatocyte
  • hormone
  • liver

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2023 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use