{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM641342": {"AGE": 53, "INDIVIDUAL": "Patient 4", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641343": {"AGE": 53, "INDIVIDUAL": "Patient 4", "TREATMENT": "BETAFERON", "TIME": "3 month of BETAFERON"}}, {"GSM641344": {"AGE": 53, "INDIVIDUAL": "Patient 4", "TREATMENT": "BETAFERON", "TIME": "12 month of BETAFERON"}}, {"GSM641345": {"AGE": 53, "INDIVIDUAL": "Patient 4", "TREATMENT": "BETAFERON", "TIME": "24 month of BETAFERON"}}, {"GSM641346": {"AGE": 52, "INDIVIDUAL": "Patient 13", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641347": {"AGE": 52, "INDIVIDUAL": "Patient 13", "TREATMENT": "REBIF", "TIME": "3 month of REBIF"}}, {"GSM641348": {"AGE": 52, "INDIVIDUAL": "Patient 13", "TREATMENT": "REBIF", "TIME": "12 month of REBIF"}}, {"GSM641349": {"AGE": 52, "INDIVIDUAL": "Patient 13", "TREATMENT": "REBIF", "TIME": "24 month of REBIF"}}, {"GSM641350": {"AGE": 50, "INDIVIDUAL": "Patient 999", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM64135": {"AGE": 50, "INDIVIDUAL": "Patient 999", "TREATMENT": "BETAFERON", "TIME": "3 month of BETAFERON"}}, {"GSM641352": {"AGE": 50, "INDIVIDUAL": "Patient 999", "TREATMENT": "BETAFERON", "TIME": "12 month of BETAFERON"}}, {"GSM641353": {"AGE": 50, "INDIVIDUAL": "Patient 999", "TREATMENT": "BETAFERON", "TIME": "24 month of BETAFERON"}}, {"GSM641354": {"AGE": 50, "INDIVIDUAL": "Patient 998", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641355": {"AGE": 50, "INDIVIDUAL": "Patient 998", "TREATMENT": "BETAFERON", "TIME": "3 month of BETAFERON"}}, {"GSM641356": {"AGE": 50, "INDIVIDUAL": "Patient 998", "TREATMENT": "BETAFERON", "TIME": "12 month of BETAFERON"}}, {"GSM641357": {"AGE": 50, "INDIVIDUAL": "Patient 998", "TREATMENT": "BETAFERON", "TIME": "24 month of BETAFERON"}}, {"GSM641358": {"AGE": 33, "INDIVIDUAL": "Patient 108", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641359": {"AGE": 33, "INDIVIDUAL": "Patient 108", "TREATMENT": "BETAFERON", "TIME": "3 month of BETAFERON"}}, {"GSM641360": {"AGE": 33, "INDIVIDUAL": "Patient 108", "TREATMENT": "BETAFERON", "TIME": "12 month of BETAFERON"}}, {"GSM64136": {"AGE": 33, "INDIVIDUAL": "Patient 108", "TREATMENT": "BETAFERON", "TIME": "24 month of BETAFERON"}}, {"GSM641362": {"AGE": 35, "INDIVIDUAL": "Patient 112", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641363": {"AGE": 35, "INDIVIDUAL": "Patient 112", "TREATMENT": "REBIF", "TIME": "3 month of REBIF"}}, {"GSM641364": {"AGE": 35, "INDIVIDUAL": "Patient 112", "TREATMENT": "REBIF", "TIME": "12 month of REBIF"}}, {"GSM641365": {"AGE": 35, "INDIVIDUAL": "Patient 112", "TREATMENT": "REBIF", "TIME": "24 month of REBIF"}}, {"GSM641366": {"AGE": 36, "INDIVIDUAL": "Patient 113", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM641367": {"AGE": 36, "INDIVIDUAL": "Patient 113", "TREATMENT": "REBIF", "TIME": "3 month of REBIF"}}, {"GSM641368": {"AGE": 36, "INDIVIDUAL": "Patient 113", "TREATMENT": "REBIF", "TIME": "12 month of REBIF"}}, {"GSM641369": {"AGE": 36, "INDIVIDUAL": "Patient 113", "TREATMENT": "REBIF", "TIME": "24 month of REBIF"}}, {"GSM641370": {"AGE": 36, "INDIVIDUAL": "Patient 116", "TREATMENT": "baseline", "TIME": "baseline"}}, {"GSM64137": {"AGE": 36, "INDIVIDUAL": "Patient 116", "TREATMENT": "REBIF", "TIME": "3 month of REBIF"}}, {"GSM641372": {"AGE": 36, "INDIVIDUAL": "Patient 116", "TREATMENT": "REBIF", "TIME": "12 month of REBIF"}}, {"GSM641373": {"AGE": 36, "INDIVIDUAL": "Patient 116", "TREATMENT": "REBIF", "TIME": "24 month of REBIF"}}], "id": 3893, "pop_total": 0, "platform": 4, "summary_wrapped": "We aimed to identify specific biomarkers of IFN-beta bioactivity in order to compare their gene expression induction by type I IFNs with...", "geo_gse_id": "E-GEOD-26104", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 32, "tags": [], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "search-for-specific-biomarkers-of-ifn-beta-bioacti", "geo_id_plat": "E-GEOD-26104_A-AFFY-44", "name": "Search for specific biomarkers of IFN-beta bioactivity in patients with MS", "created": "Sep.15, 2014", "summary": "We aimed to identify specific biomarkers of IFN-beta bioactivity in order to compare their gene expression induction by type I IFNs with the MxA, and to investigate their potential role in MS pathogenesis. Gene expression microarrays were performed in PBMC from MS patients who developed neutralizing antibodies (NAB) to IFN-beta. Nine genes followed patterns in gene expression over time similar to the MX1 and were selected for further experiments: IFI6, IFI27, IFI44L, IFIT1, HERC5, LY6E, RSAD2, SIGLEC1, and USP18. In vitro experiments revealed specific induction of selected biomarkers by IFN-beta but not IFN-gamma, and several markers, in particular USP18 and HERC5, were significantly induced at lower IFN-beta concentrations and more selective than the MX1 as biomarkers of IFN-beta bioactivity. In addition, USP18 expression was deficient in MS patients compared with healthy controls (p=0.0004). We propose specific biomarkers that may be considered in addition to the MxA to evaluate IFN-beta bioactivity, and to further explore their implication in MS pathogenesis. Number of samples: 32. We analyzed PBMC from 8 patients at baseline and after 3, 12 and 24 months of IFN-beta treatment", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26104", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-26104/samples/"}