ArrayExpress Uploader06297Dot1l -/-3Dot1l -/-3Dot1l -/-3Dot1l -/-3Dot1l -/-3Dot1l flox/flox3Dot1l flox/flox3Dot1l flox/flox3Dot1l flox/flox3Dot1l -/-5Dot1l -/-5Dot1l -/-5Dot1l -/-5Dot1l -/-5Dot1l flox/flox5Dot1l flox/flox5Dot1l flox/flox5Dot1l flox/flox5Dot1l flox/flox5Dot1l -/-7Dot1l -/-7Dot1l -/-7Dot1l flox/flox7Dot1l flox/flox7Dot1l flox/flox7Dot1l flox/flox7arrayexpress_sid6MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters....21741597E-GEOD-25911/profile/8773/arrayexpressuploader226bonebone marrowhistoneleukemiaDec.12, 2014Falseexpression-changes-after-loss-of-dot1l-in-murine-mE-GEOD-25911_A-AFFY-45Expression changes after loss of Dot1l in murine MLL-AF9 leukemia cellsNov.11, 2014MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone marrow cells. MLL-AF9 murine leukemia cells carrying two conditional Dot1l alleles were retrovirally transduced with Cre or empty control vector, and gene expression changes were monitored on day 3, 5, and 7 after transduction.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25911mousehttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25911/samples/