ArrayExpress Uploader03882MALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyMALT lymphomalymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyDLBCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsyFCLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsySMZLlymphomafrozen biopsyhealthy controlcentroblatstonsilhealthy controlcentroblatstonsilhealthy controlCD19+bloodhealthy controlCD19+bloodhealthy controlCD19+, αIgM,αCD40,IL4, 24hbloodhealthy controlCD19+, αIgM,αCD40,IL4, 24hbloodhealthy controlIgM+IgD+CD27+bloodhealthy controlIgM+IgD+CD27+bloodhealthy controlmemory B cellstonsilhealthy controlmemory B cellstonsilhealthy controlnaive B cellstonsilhealthy controlnaive B cellstonsilhealthy controlT cellstonsilarrayexpress_sid4Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT)...22689981E-GEOD-25638/profile/8773/arrayexpressuploader397celldiseaselymphocytelymphoid tissuelymphomamalt lymphomamucosamucosa-associated lymphoid tissueDec.12, 2014FalseE-GEOD-25638_A-AFFY-44a-mouse-model-of-deregulation-of-the-malt1-oncogenA mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset]Sep.15, 2014Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NF-kappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies. Keywords: lymphoma profiling, MALT lymphoma 97 samples were analized of which 13 were normal B-cell purified subpopulations and 84 lymphoma samples (31 MALT lymphomas, 26 DLBCL, 15 FCL and 12 SMZL)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25638humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25638/samples/