{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3882, "factors": [{"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629894": {"DISEASE STATUS": "MALT lymphoma", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629925": {"DISEASE STATUS": "DLBCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM62995": {"DISEASE STATUS": "FCL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629966": {"DISEASE STATUS": "SMZL", "CELL TYPE": "lymphoma", "ORGANISM PART": "frozen biopsy"}}, {"GSM629978": {"DISEASE STATUS": "healthy control", "CELL TYPE": "centroblats", "ORGANISM PART": "tonsil"}}, {"GSM629978": {"DISEASE STATUS": "healthy control", "CELL TYPE": "centroblats", "ORGANISM PART": "tonsil"}}, {"GSM629980": {"DISEASE STATUS": "healthy control", "CELL TYPE": "CD19+", "ORGANISM PART": "blood"}}, {"GSM629980": {"DISEASE STATUS": "healthy control", "CELL TYPE": "CD19+", "ORGANISM PART": "blood"}}, {"GSM629982": {"DISEASE STATUS": "healthy control", "CELL TYPE": "CD19+, \u03b1IgM,\u03b1CD40,IL4, 24h", "ORGANISM PART": "blood"}}, {"GSM629982": {"DISEASE STATUS": "healthy control", "CELL TYPE": "CD19+, \u03b1IgM,\u03b1CD40,IL4, 24h", "ORGANISM PART": "blood"}}, {"GSM629984": {"DISEASE STATUS": "healthy control", "CELL TYPE": "IgM+IgD+CD27+", "ORGANISM PART": "blood"}}, {"GSM629984": {"DISEASE STATUS": "healthy control", "CELL TYPE": "IgM+IgD+CD27+", "ORGANISM PART": "blood"}}, {"GSM629986": {"DISEASE STATUS": "healthy control", "CELL TYPE": "memory B cells", "ORGANISM PART": "tonsil"}}, {"GSM629986": {"DISEASE STATUS": "healthy control", "CELL TYPE": "memory B cells", "ORGANISM PART": "tonsil"}}, {"GSM629988": {"DISEASE STATUS": "healthy control", "CELL TYPE": "naive B cells", "ORGANISM PART": "tonsil"}}, {"GSM629988": {"DISEASE STATUS": "healthy control", "CELL TYPE": "naive B cells", "ORGANISM PART": "tonsil"}}, {"GSM629990": {"DISEASE STATUS": "healthy control", "CELL TYPE": "T cells", "ORGANISM PART": "tonsil"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT)...", "pubmed_id": 22689981, "geo_gse_id": "E-GEOD-25638", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 3, "sample_count": 97, "tags": ["cell", "disease", "lymphocyte", "lymphoid tissue", "lymphoma", "malt lymphoma", "mucosa", "mucosa-associated lymphoid tissue"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-25638_A-AFFY-44", "slug": "a-mouse-model-of-deregulation-of-the-malt1-oncogen", "geo_gds_id": "", "name": "A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MALT dataset]", "created": "Sep.15, 2014", "summary": "Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NF-kappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies.  Keywords: lymphoma profiling, MALT lymphoma 97 samples were analized of which 13 were normal B-cell purified subpopulations and 84 lymphoma samples (31 MALT lymphomas, 26 DLBCL, 15 FCL and 12 SMZL)", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25638", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25638/samples/"}