{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 6281, "factors": [{"GSM629885": {"DISEASE STATUS": "healthy control", "VARIATION": "wild type"}}, {"GSM629885": {"DISEASE STATUS": "healthy control", "VARIATION": "wild type"}}, {"GSM629885": {"DISEASE STATUS": "healthy control", "VARIATION": "wild type"}}, {"GSM629885": {"DISEASE STATUS": "healthy control", "VARIATION": "wild type"}}, {"GSM629889": {"DISEASE STATUS": "lymphoma", "VARIATION": "Sca1-MALT1"}}, {"GSM629889": {"DISEASE STATUS": "lymphoma", "VARIATION": "Sca1-MALT1"}}, {"GSM629889": {"DISEASE STATUS": "lymphoma", "VARIATION": "Sca1-MALT1"}}, {"GSM629889": {"DISEASE STATUS": "lymphoma", "VARIATION": "Sca1-MALT1"}}, {"GSM629889": {"DISEASE STATUS": "lymphoma", "VARIATION": "Sca1-MALT1"}}], "pop_total": 0, "platform": 6, "summary_wrapped": "Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT)...", "pubmed_id": 22689981, "geo_gse_id": "E-GEOD-25637", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 9, "tags": ["cell", "disease", "lymphocyte", "lymphoid tissue", "lymphoma", "malt lymphoma", "mucosa", "mucosa-associated lymphoid tissue"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-25637_A-AFFY-45", "slug": "a-mouse-model-of-deregulation-of-the-malt1-oncog-3", "geo_gds_id": "", "name": "A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [Spleen dataset]", "created": "Nov.11, 2014", "summary": "Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NFkappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies.  Keywords: Genetic modification, wt vs. transgenic, disease analysis, MALT lymphoma 9 samples were analized of which 5 were splenic lymphomas from Sca1-MALT1 transgenic mice and 4 were spleens from WT mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25637", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25637/samples/"}