ArrayExpress Uploader0mousewild typewild typewild typeSca1-MALT1Sca1-MALT1Sca1-MALT1Sca1-MALT1Sca1-MALT16280arrayexpress_sid6Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT)...22689981E-GEOD-25636/profile/8773/arrayexpressuploader18celldiseaselymphocytelymphoid tissuelymphomamalt lymphomamucosamucosa-associated lymphoid tissueDec.12, 2014FalseE-GEOD-25636_A-AFFY-45a-mouse-model-of-deregulation-of-the-malt1-oncog-2A mouse model of deregulation of the malt1 oncogene recapitulates the pathogenesis of human malt lymphoma [MouseSca1 dataset]Nov.11, 2014Attempts at modeling chromosomal translocations involving MALT1 gene, hallmarks of human mucosa-associated lymphoid tissue (MALT) lymphoma, have failed to reproduce the disease in mice. Here we describe a transgenic model in which MALT1 expression was targeted to mouse hematopoietic stem/progenitor cells. In Sca1-MALT1 mice, MALT1 deregulation activated the NF-kappaB pathway in Sca1+ cells, promoting selective B-cell differentiation and mature lymphocyte accumulation in extranodal tissues, progressively leading to the development of clonal B-cell lymphomas. These tumors recapitulated the histopathological features of human MALT lymphomas, presenting typical lymphoepithelial lesions and plasmacytic differentiation. Transcriptional profiling of Sca1-MALT1 murine lymphomas revealed overlapping molecular signatures with human MALT lymphomas, including MALT1-mediated NFkappaB activation, pro-inflammatory signaling and XBP1-induced plasmacytic differentiation. Moreover, murine Malt1 showed proteolytic activity by cleaving Bcl10 in Sca1-MALT1 lymphomas. Our novel technological approach has allowed modeling human MALT lymphoma in mice, which represent unique tools study MALT lymphoma biology and evaluate anti-MALT1 therapies. Keywords: Genetic modification, wt vs. transgenic, MALT1 expression 8 sorting purified Sca1+Lin- samples were analized of which 5 were from Sca1-MALT1 transgenic mice and 3 were from WT mice.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25636http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25636/samples/