{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM618135": {"TRASNFECTION PROTOCOL": "CREB3L1\u0394381-519"}}, {"GSM618136": {"TRASNFECTION PROTOCOL": "empty vector control"}}], "id": 3858, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Membrane-bound transcription factor CREB3L1 undergoes Regulated Intramembrane Proteolysis (RIP) in response to Hepatitis C infection....", "geo_gse_id": "E-GEOD-25157", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 2, "tags": ["cell", "hepatitis", "hepatitis c infection", "membrane"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-25157_A-AFFY-44", "slug": "creb3l1-target-genes-in-response-to-hepatitis-c-re", "geo_gds_id": "", "name": "CREB3L1 Target Genes in Response to Hepatitis C Replicon Infection", "created": "Sep.15, 2014", "summary": "Membrane-bound transcription factor CREB3L1 undergoes Regulated Intramembrane Proteolysis (RIP) in response to Hepatitis C infection.  RIP activates CREB3L1 so that it can prevent the growth of HCV infected cells through the action of downstream genes.  We over-expressed a truncated form of CREB3L1 that does not require RIP to enter the nucleus.  Cells over-expressing this truncated form were isolated by Fluorescence Activated Cell Sorting (FACS). We used microarray to determine the downstream genes of CREB3L1 in comparison to a flow sorted empty vector control. HCV Replicon-containing cells were transfected with a CREB3L1\u0394381-519 to determine the downstream genes.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25157", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25157/samples/"}