ArrayExpress Uploader0mouseAnterior prostate tissuewild-typeAnterior prostate tissuewild-typeAnterior prostate tissuewild-typeAnterior prostate tumorProstate-specific Pten deletionAnterior prostate tumorProstate-specific Pten deletionAnterior prostate tumorProstate-specific Pten deletionAnterior prostate tumorProstate-specific Pten deletionAnterior prostate tumorProstate-specific Pten deletionAnterior prostate tumorProstate-specific Pten and Smad4 deletionAnterior prostate tumorProstate-specific Pten and Smad4 deletionAnterior prostate tumorProstate-specific Pten and Smad4 deletionAnterior prostate tumorProstate-specific Pten and Smad4 deletionAnterior prostate tumorProstate-specific Pten and Smad4 deletionAnterior prostate tumorProstate-specific Pten and p53 deletionAnterior prostate tumorProstate-specific Pten and p53 deletionAnterior prostate tumorProstate-specific Pten and p53 deletion6259arrayexpress_sid6We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior...E-GEOD-25140/profile/8773/arrayexpressuploader216adenocarcinomaanteriorprostateDec.12, 2014Falseprostate-specific-pten-deletion-pten-smad4-deletioE-GEOD-25140_A-AFFY-45Prostate specific Pten deletion, Pten-Smad4 deletion, and Pten-p53 deletionNov.11, 2014We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior prostates and Ptenpc-/- anterior prostates, Ptenpc-/-Smad4pc-/- and Ptenpc-/- anterior prostates, Ptenpc-/-p53pc-/- and Ptenpc-/- anterior prostates at 15 weeks of age. Prostate-specific Pten deletion (Ptenpc-/-) results in prostate intraepithelial neoplasia (PIN) which, following a long latency, can progress to high-grade adenocarcinoma, albeit with minimally invasive and metastatic features. To understand this feeble progression phenotype, we conducted transcriptome comparison of five Ptenpc-/- PIN relative to three wild-type anterior prostate. Moreover, Ptenpc-/-Smad4pc-/- progress to metastasis, while Ptenpc-/-p53pc-/- not progress to metastasis. To understand this phenotype difference, we conducted transcriptome comparison of five Ptenpc-/-Smad4pc-/-to five Ptenpc-/- prostate tumor, and three Ptenpc-/-p53pc-/- to five Ptenpc-/- tumor.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25140http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25140/samples/