{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM61788": {"TISSUE": "Anterior prostate tissue", "GENOTYPE": "wild-type"}}, {"GSM61788": {"TISSUE": "Anterior prostate tissue", "GENOTYPE": "wild-type"}}, {"GSM61788": {"TISSUE": "Anterior prostate tissue", "GENOTYPE": "wild-type"}}, {"GSM617884": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten deletion"}}, {"GSM617884": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten deletion"}}, {"GSM617884": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten deletion"}}, {"GSM617884": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten deletion"}}, {"GSM617884": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten deletion"}}, {"GSM617889": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and Smad4 deletion"}}, {"GSM617889": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and Smad4 deletion"}}, {"GSM617889": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and Smad4 deletion"}}, {"GSM617889": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and Smad4 deletion"}}, {"GSM617889": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and Smad4 deletion"}}, {"GSM617894": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and p53 deletion"}}, {"GSM617894": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and p53 deletion"}}, {"GSM617894": {"TISSUE": "Anterior prostate tumor", "GENOTYPE": "Prostate-specific Pten and p53 deletion"}}], "id": 6259, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior...", "geo_gse_id": "E-GEOD-25140", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 16, "tags": ["adenocarcinoma", "anterior", "prostate"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "prostate-specific-pten-deletion-pten-smad4-deletio", "geo_id_plat": "E-GEOD-25140_A-AFFY-45", "name": "Prostate specific Pten deletion, Pten-Smad4 deletion, and Pten-p53 deletion", "created": "Nov.11, 2014", "summary": "We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior prostates and Ptenpc-/- anterior prostates, Ptenpc-/-Smad4pc-/- and Ptenpc-/- anterior prostates, Ptenpc-/-p53pc-/- and Ptenpc-/- anterior prostates at 15 weeks of age. Prostate-specific Pten deletion (Ptenpc-/-) results in prostate intraepithelial neoplasia (PIN) which, following a long latency, can progress to high-grade adenocarcinoma, albeit with minimally invasive and metastatic features.  To understand this feeble progression phenotype, we conducted transcriptome comparison of five Ptenpc-/- PIN relative to three wild-type anterior prostate.  Moreover,  Ptenpc-/-Smad4pc-/- progress to metastasis, while Ptenpc-/-p53pc-/- not progress to metastasis.   To understand this phenotype difference, we conducted transcriptome comparison of five Ptenpc-/-Smad4pc-/-to five Ptenpc-/- prostate tumor, and three Ptenpc-/-p53pc-/- to five Ptenpc-/- tumor.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25140", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25140/samples/"}