Dataset: Prostate specific Pten deletion, Pten-Smad4 deletion, and Pten-p53 deletion
We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior...
We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior prostates and Ptenpc-/- anterior prostates, Ptenpc-/-Smad4pc-/- and Ptenpc-/- anterior prostates, Ptenpc-/-p53pc-/- and Ptenpc-/- anterior prostates at 15 weeks of age. Prostate-specific Pten deletion (Ptenpc-/-) results in prostate intraepithelial neoplasia (PIN) which, following a long latency, can progress to high-grade adenocarcinoma, albeit with minimally invasive and metastatic features. To understand this feeble progression phenotype, we conducted transcriptome comparison of five Ptenpc-/- PIN relative to three wild-type anterior prostate. Moreover, Ptenpc-/-Smad4pc-/- progress to metastasis, while Ptenpc-/-p53pc-/- not progress to metastasis. To understand this phenotype difference, we conducted transcriptome comparison of five Ptenpc-/-Smad4pc-/-to five Ptenpc-/- prostate tumor, and three Ptenpc-/-p53pc-/- to five Ptenpc-/- tumor.
- Species:
- mouse
- Samples:
- 16
- Source:
- E-GEOD-25140
- Updated:
- Dec.12, 2014
- Registered:
- Nov.11, 2014
| Sample | TISSUE | GENOTYPE |
|---|---|---|
| GSM61788 | Anterior prostate tissue | wild-type |
| GSM61788 | Anterior prostate tissue | wild-type |
| GSM61788 | Anterior prostate tissue | wild-type |
| GSM617884 | Anterior prostate tumor | Prostate-specific Pten deletion |
| GSM617884 | Anterior prostate tumor | Prostate-specific Pten deletion |
| GSM617884 | Anterior prostate tumor | Prostate-specific Pten deletion |
| GSM617884 | Anterior prostate tumor | Prostate-specific Pten deletion |
| GSM617884 | Anterior prostate tumor | Prostate-specific Pten deletion |
| GSM617889 | Anterior prostate tumor | Prostate-specific Pten and Smad4 deletion |
| GSM617889 | Anterior prostate tumor | Prostate-specific Pten and Smad4 deletion |
| GSM617889 | Anterior prostate tumor | Prostate-specific Pten and Smad4 deletion |
| GSM617889 | Anterior prostate tumor | Prostate-specific Pten and Smad4 deletion |
| GSM617889 | Anterior prostate tumor | Prostate-specific Pten and Smad4 deletion |
| GSM617894 | Anterior prostate tumor | Prostate-specific Pten and p53 deletion |
| GSM617894 | Anterior prostate tumor | Prostate-specific Pten and p53 deletion |
| GSM617894 | Anterior prostate tumor | Prostate-specific Pten and p53 deletion |