{"platform": 6, "owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM617163": {"ACTIVATION": "control", "MOUSE": 1, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617164": {"ACTIVATION": "control", "MOUSE": 1, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617165": {"ACTIVATION": "IL-4", "MOUSE": 1, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617166": {"ACTIVATION": "IL-4", "MOUSE": 1, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617167": {"ACTIVATION": "control", "MOUSE": 2, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617168": {"ACTIVATION": "control", "MOUSE": 2, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617169": {"ACTIVATION": "IL-4", "MOUSE": 2, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617170": {"ACTIVATION": "IL-4", "MOUSE": 2, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM61717": {"ACTIVATION": "control", "MOUSE": 3, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617172": {"ACTIVATION": "control", "MOUSE": 3, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617173": {"ACTIVATION": "IL-4", "MOUSE": 3, "TREATMENT": "control", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617174": {"ACTIVATION": "IL-4", "MOUSE": 3, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg +/-LysCre"}}, {"GSM617175": {"ACTIVATION": "control", "MOUSE": 4, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617176": {"ACTIVATION": "control", "MOUSE": 4, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617177": {"ACTIVATION": "IL-4", "MOUSE": 4, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617178": {"ACTIVATION": "IL-4", "MOUSE": 4, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617179": {"ACTIVATION": "control", "MOUSE": 5, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617180": {"ACTIVATION": "control", "MOUSE": 5, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM61718": {"ACTIVATION": "IL-4", "MOUSE": 5, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617182": {"ACTIVATION": "IL-4", "MOUSE": 5, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617183": {"ACTIVATION": "control", "MOUSE": 6, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617184": {"ACTIVATION": "control", "MOUSE": 6, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617185": {"ACTIVATION": "IL-4", "MOUSE": 6, "TREATMENT": "control", "VARIATION": "PPARg fl/-LysCre"}}, {"GSM617186": {"ACTIVATION": "IL-4", "MOUSE": 6, "TREATMENT": "rosiglitazone", "VARIATION": "PPARg fl/-LysCre"}}], "id": 6258, "ownerprofile_id": "arrayexpress_sid", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25123", "summary_wrapped": "Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed,...", "pubmed_id": 21093321, "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 4, "sample_count": 24, "tags": ["bone", "bone marrow", "genome", "macrophage"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "pparg-and-il-4-induced-gene-expression-data-from-p", "geo_id_plat": "E-GEOD-25123_A-AFFY-45", "name": "PPARg and IL-4-induced gene expression data from PPARg +/- LysCre and PPARg fl/- LysCre mouse bone marrow-derived macrophages", "created": "Nov.11, 2014", "summary": "Conditional macrophage-specific PPARg knockout mice were generated on C57Bl/6 background by breeding PPARg fl/- (one allele is floxed, the other is null) and lysozyme Cre transgenic mice. PPARg and IL-4 signaling was analyzed on bone marrow-derived macrophages. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate PPARg. From each mouse 4 samples were generated: 1. M-CSF, 2. M-CSF+RSG, 3. IL-4 and 4. IL-4+RSG. All compounds were added throughout the whole differentiation process, and fresh media was added every other day. Control cells were treated with vehicle (DMSO:ethanol). After 10 days, RNA was isolated and gene expression profiles were analyzed using Mouse Genome 430 2.0 microarrays from Affymetrix. 3 PPARg +/- LysCre and 3 PPARg fl/- LysCre mice were used to isolate bone marrow and from each macrophages were differentiated with or without IL-4 and simultaneously treated with vehicle or RSG. Altogether we analyzed 24 samples with 3 biological replicates as below.", "geo_gse_id": "E-GEOD-25123", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25123/samples/"}