{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3849, "factors": [{"GSM617134": {"DOSE": "n/a", "COMPOUND": "Vehicle"}}, {"GSM617134": {"DOSE": "n/a", "COMPOUND": "Vehicle"}}, {"GSM617136": {"DOSE": "4mg/kg", "COMPOUND": "CH5424802"}}, {"GSM617136": {"DOSE": "4mg/kg", "COMPOUND": "CH5424802"}}, {"GSM617138": {"DOSE": "20mg/kg", "COMPOUND": "CH5424802"}}, {"GSM617138": {"DOSE": "20mg/kg", "COMPOUND": "CH5424802"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor...", "pubmed_id": 21575866, "geo_gse_id": "E-GEOD-25118", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 6, "tags": ["nsclc"], "lastmodified": "Jun.29, 2015", "is_default": false, "geo_gds_id": "", "slug": "regulation-of-gene-expression-in-alk-inhibitor-ch5", "geo_id_plat": "E-GEOD-25118_A-AFFY-44", "name": "Regulation of gene expression in ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors", "created": "Sep.15, 2014", "summary": "To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK. Mice bearing NCI-H2228 cells were orally administered at dose of 0 (vehicle), 4 or 20 mg/kg of CH5424802, and the tumors were collected and lysed at 6 hours post-dose. Total RNA were extracted from xenograft tumors.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25118", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25118/samples/"}