ArrayExpress Uploader03849n/aVehiclen/aVehicle4mg/kgCH54248024mg/kgCH542480220mg/kgCH542480220mg/kgCH5424802arrayexpress_sid4To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor...21575866E-GEOD-25118/profile/8773/arrayexpressuploader26nsclcJun.29, 2015Falseregulation-of-gene-expression-in-alk-inhibitor-ch5E-GEOD-25118_A-AFFY-44Regulation of gene expression in ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumorsSep.15, 2014To clarify the downstream signal pathway of EML4-ALK in NSCLC, we performed Affymetrix GeneChip analysis using ALK inhibitor CH5424802-treated NCI-H2228 xenograft tumors, and comprehensively characterized the gene expression regulated by inhibition of activated ALK. Mice bearing NCI-H2228 cells were orally administered at dose of 0 (vehicle), 4 or 20 mg/kg of CH5424802, and the tumors were collected and lysed at 6 hours post-dose. Total RNA were extracted from xenograft tumors.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25118humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-25118/samples/