ArrayExpress Uploaderarrayexpress_sidmouseKOIL17KOIL17KOIL17KOIL17KOIL17KOIL17KOTNFaKOTNFaKOTNFaKOTNFaKOTNFaKOTNFaKOIL17 and TNFaKOIL17 and TNFaKOIL17 and TNFaKOIL17 and TNFaKOIL17 and TNFaKOIL17 and TNFaKOnoneKOnoneKOnoneKOnoneKOnoneKOnoneWTIL17WTIL17WTIL17WTIL17WTIL17WTIL17WTTNFaWTTNFaWTTNFaWTTNFaWTTNFaWTTNFaWTIL17 and TNFaWTIL17 and TNFaWTIL17 and TNFaWTIL17 and TNFaWTIL17 and TNFaWTIL17 and TNFaWTnoneWTnoneWTnoneWTnoneWTnoneWTnone625006Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also...21335551E-GEOD-24873/profile/8773/arrayexpressuploader248autoimmune diseasediseaseembryointerleukininterleukin-17proteinDec.12, 2014Falseil-17-induced-nf-kb-activation-via-ciksact1-physioE-GEOD-24873_A-AFFY-45IL-17-induced NF-kB activation via CIKS/Act1: Physiologic significance and signaling mechanismsNov.11, 2014Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of the adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domains and to activation of the transcription factor NF-kB; it is not known whether CIKS and/or NF-kB are required for all gene induction events. Here we report that CIKS is essential for all IL-17 induced immediate-early genes in primary mouse embryo fibroblasts, while NF-kB is profoundly involved.  We also identify a novel sub-domain in the N-terminus of CIKS that is essential for IL-17-mediated NF-kB activation. This domain is both necessary and sufficient for the interaction between CIKS and TRAF6, an adaptor required for NF-kB activation.  The ability of decoy peptides to block this interaction may provide a new therapeutic strategy for intervention in IL-17-driven autoimmune and inflammatory diseases. Keywords: strain comparisons strain comparisonshttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24873http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24873/samples/