{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611612": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611618": {"GENOTYPE VARIATION": "KO", "TREATMENT": "TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611624": {"GENOTYPE VARIATION": "KO", "TREATMENT": "IL17 and TNFa"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611630": {"GENOTYPE VARIATION": "KO", "TREATMENT": "none"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611636": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611642": {"GENOTYPE VARIATION": "WT", "TREATMENT": "TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611648": {"GENOTYPE VARIATION": "WT", "TREATMENT": "IL17 and TNFa"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}, {"GSM611654": {"GENOTYPE VARIATION": "WT", "TREATMENT": "none"}}], "id": 6250, "pop_total": 0, "platform": 6, "summary_wrapped": "Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also...", "pubmed_id": 21335551, "geo_gse_id": "E-GEOD-24873", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 48, "tags": ["autoimmune disease", "disease", "embryo", "interleukin", "interleukin-17", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "il-17-induced-nf-kb-activation-via-ciksact1-physio", "geo_id_plat": "E-GEOD-24873_A-AFFY-45", "name": "IL-17-induced NF-kB activation via CIKS/Act1: Physiologic significance and signaling mechanisms", "created": "Nov.11, 2014", "summary": "Interleukin-17 (IL-17) is essential in host defense against extracellular bacteria and fungi, especially at mucosal sites, but it also contributes significantly to inflammatory and autoimmune disease pathologies. Binding of IL-17 to its receptor leads to recruitment of the adaptor protein CIKS/Act1 via heterotypic association of their respective SEFIR domains and to activation of the transcription factor NF-kB; it is not known whether CIKS and/or NF-kB are required for all gene induction events. Here we report that CIKS is essential for all IL-17 induced immediate-early genes in primary mouse embryo fibroblasts, while NF-kB is profoundly involved.\u00a0 We also identify a novel sub-domain in the N-terminus of CIKS that is essential for IL-17-mediated NF-kB activation. This domain is both necessary and sufficient for the interaction between CIKS and TRAF6, an adaptor required for NF-kB activation.\u00a0 The ability of decoy peptides to block this interaction may provide a new therapeutic strategy for intervention in IL-17-driven autoimmune and inflammatory diseases.  Keywords: strain comparisons strain comparisons", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24873", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24873/samples/"}