ArrayExpress Uploaderarrayexpress_sidmousenon-malignantnon-malignantnon-malignantintermediateintermediateintermediatemalignantmalignantmalignant624606Ovarian cancer is one of the most deadly cancers accounting for only 3% of diagnosed cancers, but is the fifth leading cause of cancer...E-GEOD-24789/profile/8773/arrayexpressuploader19cancercellintermediateovarian cancersurfaceDec.12, 2014Falseexpression-data-from-mouse-ovarian-surface-epithelE-GEOD-24789_A-AFFY-45Expression data from mouse ovarian surface epithelium cells at different stages of malignancyNov.11, 2014Ovarian cancer is one of the most deadly cancers accounting for only 3% of diagnosed cancers, but is the fifth leading cause of cancer deaths among woman; however, the progression of ovarian cancer is poorly understood. To study and further understand the early events that lead to epithelial derived ovarian cancer, we previously developed a cell model of progressive ovarian cancer. Mouse ovarian surface epithelial (MOSE) cells have undergone spontaneous transformation in cell culture and represent pre-neoplastic, non-tumorigenic to an aggressive malignant phenotype. Microarray analysis was performed with RNA isolated from different stages of MOSE cells to examine changes in gene expression as MOSE cells transition from a pre-neoplastic to a malignant state. RNA was isolated from MOSE early cell representing a pre-neoplastic, non-malignant stage, MOSE Intermediate cells representing a noeplastic, pre-invasive state, and MOSE Late cells representing a malignant, invasive stage. Three biological replicates were used to take into account variations within the heterogeneous cultures.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24789http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24789/samples/