ArrayExpress Uploader0mousecontrolHsp22 WTcontrolHsp22 WTcontrolHsp22 WTcontrolHsp22 KOcontrolHsp22 KOcontrolHsp22 KOpressure overloadHsp22 WTpressure overloadHsp22 WTpressure overloadHsp22 WTpressure overloadHsp22 WTpressure overloadHsp22 KOpressure overloadHsp22 KOpressure overloadHsp22 KOpressure overloadHsp22 KO6232arrayexpress_sid6The expression of the small molecular weight heat shock protein (Hsp) H11 kinase/Hsp22 (Hsp22) is restricted to a limited number of...E-GEOD-24489/profile/8773/arrayexpressuploader214basalheartleftmuscleproteintransverseDec.12, 2014Falseeffect-of-h11-kinasehsp22-deletion-in-response-toE-GEOD-24489_A-AFFY-45Effect of H11 Kinase/Hsp22 deletion in response to cardiac stressNov.11, 2014The expression of the small molecular weight heat shock protein (Hsp) H11 kinase/Hsp22 (Hsp22) is restricted to a limited number of tissues, including the heart and skeletal muscle, both in rodents and in humans. We generated a mouse knockout (KO) model, and investigated the role of Hsp22 in regulating cardiac hypertrophy in response to pressure overload. We compared gene expression profiles between WT and KO mice in basal condition and three days pressure overload after transverse aortic constriction (TAC). These data illustrated a novel mechanism of Hsp22-related gene expression in response to cardiac stress. We used microarray to examine differential gene expression by Hsp22 deletion at baseline and 3-day pressure overload. Left ventricles from wild type and Hsp22 knockout mice were selected from basal condition (each, n=3) and TAC surgery (each, n=4).http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24489http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24489/samples/