Dataset: Expression data of multiple sclerosis patients receiving Interferon-beta therapy
The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250...
The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression profiles of peripheral blood mononuclear cells from 25 MS patients within the first two years of IFN-beta administration. EDTA blood samples were drawn from all patients immediately before first, second, month 1, 12, and 24 IFN-beta injection. Total RNA of Ficoll-isolated peripheral blood mononuclear cells from each sample was extracted, labelled and hybridized to Affymetrix Human Genome U133 A and B arrays to quantify the mRNA levels.
- Species:
- human
- Samples:
- 125
- Source:
- E-GEOD-24427
- PubMed:
- 20136355
- Updated:
- Jan.17, 2015
- Registered:
- Jan.17, 2015
Factors:
(via ArrayExpress)
| Sample | EDSS | AGE | GENDER |
|---|---|---|---|
| GSM601747 1 | 4.0 | 63.2 | female |
| GSM601748 1 | 4.0 | 63.2 | female |
| GSM601749 1 | 4.0 | 63.2 | female |
| GSM601750 1 | 4.0 | 63.2 | female |
| GSM601751 1 | 4.0 | 63.2 | female |
| GSM601752 1 | 1.0 | 45.0 | male |
| GSM601753 1 | 1.0 | 45.0 | male |
| GSM601754 1 | 1.0 | 45.0 | male |
| GSM601755 1 | 1.0 | 45.0 | male |
| GSM601756 1 | 1.0 | 45.0 | male |
| GSM601757 1 | 1.0 | 25.6 | female |
| GSM601758 1 | 1.0 | 25.6 | female |
| GSM601759 1 | 1.0 | 25.6 | female |
| GSM601760 1 | 1.0 | 25.6 | female |
| GSM601761 1 | 1.0 | 25.6 | female |
| GSM601762 1 | 4.0 | 27.9 | female |
| GSM601763 1 | 4.0 | 27.9 | female |
| GSM601764 1 | 4.0 | 27.9 | female |
| GSM601765 1 | 4.0 | 27.9 | female |
| GSM601766 1 | 4.0 | 27.9 | female |
| GSM601767 1 | 3.0 | 51.4 | female |
| GSM601768 1 | 3.0 | 51.4 | female |
| GSM601769 1 | 3.0 | 51.4 | female |
| GSM601770 1 | 3.0 | 51.4 | female |
| GSM601771 1 | 3.0 | 51.4 | female |
| GSM601772 1 | 2.0 | 41.6 | female |
| GSM601773 1 | 2.0 | 41.6 | female |
| GSM601774 1 | 2.0 | 41.6 | female |
| GSM601775 1 | 2.0 | 41.6 | female |
| GSM601776 1 | 2.0 | 41.6 | female |
| GSM601777 1 | 4.0 | 44.3 | female |
| GSM601778 1 | 4.0 | 44.3 | female |
| GSM601779 1 | 4.0 | 44.3 | female |
| GSM601780 1 | 4.0 | 44.3 | female |
| GSM601781 1 | 4.0 | 44.3 | female |
| GSM601782 1 | 1.5 | 30.9 | male |
| GSM601783 1 | 1.5 | 30.9 | male |
| GSM601784 1 | 1.5 | 30.9 | male |
| GSM601785 1 | 1.5 | 30.9 | male |
| GSM601786 1 | 1.5 | 30.9 | male |
| GSM601787 1 | 4.0 | 26.3 | female |
| GSM601788 1 | 4.0 | 26.3 | female |
| GSM601789 1 | 4.0 | 26.3 | female |
| GSM601790 1 | 4.0 | 26.3 | female |
| GSM601791 1 | 4.0 | 26.3 | female |
| GSM601792 1 | 1.0 | 42.4 | male |
| GSM601793 1 | 1.0 | 42.4 | male |
| GSM601794 1 | 1.0 | 42.4 | male |
| GSM601795 1 | 1.0 | 42.4 | male |
| GSM601796 1 | 1.0 | 42.4 | male |
| GSM601797 1 | 2.0 | 29.0 | male |
| GSM601798 1 | 2.0 | 29.0 | male |
| GSM601799 1 | 2.0 | 29.0 | male |
| GSM601800 1 | 2.0 | 29.0 | male |
| GSM601801 1 | 2.0 | 29.0 | male |
| GSM601802 1 | 1.5 | 28.2 | female |
| GSM601803 1 | 1.5 | 28.2 | female |
| GSM601804 1 | 1.5 | 28.2 | female |
| GSM601805 1 | 1.5 | 28.2 | female |
| GSM601806 1 | 1.5 | 28.2 | female |
| GSM601807 1 | 1.0 | 48.4 | female |
| GSM601808 1 | 1.0 | 48.4 | female |
| GSM601809 1 | 1.0 | 48.4 | female |
| GSM601810 1 | 1.0 | 48.4 | female |
| GSM601811 1 | 1.0 | 48.4 | female |
| GSM601812 1 | 3.5 | 47.8 | female |
| GSM601813 1 | 3.5 | 47.8 | female |
| GSM601814 1 | 3.5 | 47.8 | female |
| GSM601815 1 | 3.5 | 47.8 | female |
| GSM601816 1 | 3.5 | 47.8 | female |
| GSM601817 1 | 2.0 | 42.7 | female |
| GSM601818 1 | 2.0 | 42.7 | female |
| GSM601819 1 | 2.0 | 42.7 | female |
| GSM601820 1 | 2.0 | 42.7 | female |
| GSM601821 1 | 2.0 | 42.7 | female |
| GSM601822 1 | 3.5 | 50.3 | female |
| GSM601823 1 | 3.5 | 50.3 | female |
| GSM601824 1 | 3.5 | 50.3 | female |
| GSM601825 1 | 3.5 | 50.3 | female |
| GSM601826 1 | 3.5 | 50.3 | female |
| GSM601827 1 | 1.5 | 37.0 | male |
| GSM601828 1 | 1.5 | 37.0 | male |
| GSM601829 1 | 1.5 | 37.0 | male |
| GSM601830 1 | 1.5 | 37.0 | male |
| GSM601831 1 | 1.5 | 37.0 | male |
| GSM601832 1 | 2.0 | 43.9 | female |
| GSM601833 1 | 2.0 | 43.9 | female |
| GSM601834 1 | 2.0 | 43.9 | female |
| GSM601835 1 | 2.0 | 43.9 | female |
| GSM601836 1 | 2.0 | 43.9 | female |
| GSM601837 1 | 3.0 | 54.4 | male |
| GSM601838 1 | 3.0 | 54.4 | male |
| GSM601839 1 | 3.0 | 54.4 | male |
| GSM601840 1 | 3.0 | 54.4 | male |
| GSM601841 1 | 3.0 | 54.4 | male |
| GSM601842 1 | 1.0 | 40.8 | male |
| GSM601843 1 | 1.0 | 40.8 | male |
| GSM601844 1 | 1.0 | 40.8 | male |
| GSM601845 1 | 1.0 | 40.8 | male |
| GSM601846 1 | 1.0 | 40.8 | male |
| GSM601847 1 | 2.0 | 48.7 | female |
| GSM601848 1 | 2.0 | 48.7 | female |
| GSM601849 1 | 2.0 | 48.7 | female |
| GSM601850 1 | 2.0 | 48.7 | female |
| GSM601851 1 | 2.0 | 48.7 | female |
| GSM601852 1 | 2.0 | 38.2 | female |
| GSM601853 1 | 2.0 | 38.2 | female |
| GSM601854 1 | 2.0 | 38.2 | female |
| GSM601855 1 | 2.0 | 38.2 | female |
| GSM601856 1 | 2.0 | 38.2 | female |
| GSM601857 1 | 1.5 | 18.3 | male |
| GSM601858 1 | 1.5 | 18.3 | male |
| GSM601859 1 | 1.5 | 18.3 | male |
| GSM601860 1 | 1.5 | 18.3 | male |
| GSM601861 1 | 1.5 | 18.3 | male |
| GSM601862 1 | 1.0 | 24.6 | female |
| GSM601863 1 | 1.0 | 24.6 | female |
| GSM601864 1 | 1.0 | 24.6 | female |
| GSM601865 1 | 1.0 | 24.6 | female |
| GSM601866 1 | 1.0 | 24.6 | female |
| GSM601867 1 | 1.0 | 38.2 | male |
| GSM601868 1 | 1.0 | 38.2 | male |
| GSM601869 1 | 1.0 | 38.2 | male |
| GSM601870 1 | 1.0 | 38.2 | male |
| GSM601871 1 | 1.0 | 38.2 | male |