ArrayExpress Uploader0mouseCD4+/CD45RBhi/CD25- T conventional cellscontrol proteinwild-type CD4+/CD45RBhi/CD25- T conventional cellscontrol proteinwild-type CD4+/CD45RBhi/CD25- T conventional cellscontrol proteinwild-type CD4+/CD45RBhi/CD25- T conventional cellsIL35wild-type CD4+/CD45RBhi/CD25- T conventional cellsIL35wild-type CD4+/CD45RBhi/CD25- T conventional cellsIL35wild-type CD4+/CD45RBhi/CD25- T conventional cellscontrol proteinwild-type CD4+/CD45RBhi/CD25- T conventional cellscontrol proteinwild-type CD4+/CD45RBhi/CD25- T conventional cellsIL35wild-type CD4+/CD45RBhi/CD25- T conventional cellsIL35wild-type CD4+/CD45RBlow regulatory T cells (Tregs)untreatedFoxp3-GFPnot applicableCD4+/CD45RBlow regulatory T cells (Tregs)untreatedFoxp3-GFPnot applicableCD4+/CD45RBlow regulatory T cells (Tregs)untreatedFoxp3-GFPnot applicableCD4+/CD45RBhi T conventional cellsuntreatedFoxp3-GFPnot applicableCD4+/CD45RBhi T conventional cellsuntreatedFoxp3-GFPnot applicableCD4+/CD45RBhi T conventional cellsuntreatedFoxp3-GFPnot applicable6216arrayexpress_sid6Regulatory T cells (Tregs) play a critical role in the maintenance of immunological self-tolerance. Naïve human or murine T cell...E-GEOD-24210/profile/8773/arrayexpressuploader416cellcytokineDec.12, 2014Falseinterleukin-35-mediated-induction-of-a-novel-regulE-GEOD-24210_A-AFFY-45Interleukin-35-mediated induction of a novel regulatory T cell populationNov.11, 2014Regulatory T cells (Tregs) play a critical role in the maintenance of immunological self-tolerance. Naïve human or murine T cell treatment with the inhibitory cytokine IL35 induces a regulatory population, termed iTR35, that mediates suppression via IL35, but not IL10 or TGFβ, neither express nor require Foxp3, are strongly suppressive in five in vivo models, and exhibit in vivo stability. Treg-mediated suppression induces iTR35 generation in an IL35- and IL10-dependent manner in vitro, and in inflammatory conditions in vivo in Trichuris-infected intestines and within the tumor microenvironment, where they appear to contribute to the regulatory milieu. iTR35 may constitute a key mediator of infectious tolerance and may contribute to Treg-mediated tumor progression, and ex vivo-generated iTR35 may possess therapeutic utility. Five IL35-treated samples, in parallel with 5 control-treated samples, were compared to 3 Treg and 3 Tconv cell samples.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24210http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24210/samples/