ArrayExpress Uploader01291P3/35646.48wobesePOSTnUPP3/35231.6wobesePERInUPN3/33430.11wobesePREnUNN2/34935.55wobesePERInPNN3/33338.19wobesePREnNNP2/35033.12wobesePREnUPP2/34631.2wobesePREnUPP3/34930aobesePREnUPU3/36332.03wobesePOSTnUUP2/34630.12wobesePREnNPN3/34430.04bobesePERInNNP2/36130.44wobesePOSTnNPN3/34734.41wobesePREnNNN2/36835.26wobesePOSTnNPN3/35740.4bobesePOSTnNPN3/34037.5bobesePREnNNP1/35432.69aobesePOSTnNPN3/34433.06wobesePERInPNN1/36231.35wobesePOSTnNNN3/35640.53bobesePOSTyNNP1/36742.24wobesePOSTnNPN2/34731.02bobesePERInPNP3/35932.25bobesePOSTnNPP2/35131.49bobesePREnNPN3/34731.18bobesePERInNNP3/35334.72wobesePOSTnNPP3/34246.62bobesePREyNPP3/34840.26wobesePERInNPN3/35135.94bobesePOSTnNNP3/34058.47wobesePOSTyPPP3/34233.65wobesePREnNPP2/33848.27bobesePREnNPN3/34936.73wobesePOSTnNNN3/35931.89wobesePOSTyPNP3/33830.67wobesePREnNPN2/35030.82bobesePOSTnPPN2/35037.25bobesePREnNNN3/36332.89aobesePOSTyNNU3/34726.77aoverweightPERInUUN2/35125.34woverweightPOSTnUNP3/34425.06woverweightPREnUPN2/36229.82aoverweightPOSTnUNU2/34029.75woverweightPREnPPP2/33827.34woverweightPREyUPP2/35929woverweightPOSTnUNP2/34225.81woverweightPREnUPN3/35425.56woverweightPOSTnUPP3/34827.1woverweightPOSTnUPN2/35729.86aoverweightPOSTnNPN3/34527.34woverweightPREnUNN3/35828.25woverweightPOSTnNNP1/34827.61woverweightPREnUPP1/36626.18woverweightPOSTnUPN2/34225.59woverweightPREnNNP3/33027.18woverweightPREyUPN2/36129.48woverweightPOSTnNPN3/35729.21aoverweightPOSTnPNN1/35827.92woverweightPOSTnNNN2/33726.35woverweightPREnNNP2/36527.64woverweightPOSTyNPN3/35925.85boverweightPOSTnNNP3/34627.64woverweightPREyNPN3/34626.64woverweightPREnNNN1/34926.99woverweightPOSTyNPN3/34328.13woverweightPREyNNN2/33926.35woverweightPREnNNP3/34528.26woverweightPREnNPN3/33224.02wnormalPREnNNN3/35724.92wnormalPOSTnUPP2/33120.28wnormalPREnUPN2/36221.26wnormalPOSTnUNN3/35823.14wnormalPOSTnUNP2/34021.72wnormalPREnUPP2/35024.17wnormalPREnUPP3/35423.11wnormalPOSTnNPU3/36121.64wnormalPOSTnUUN3/34222.76wnormalPREnUNN3/33228.84wnormalPREnUNP1/36321.64wnormalPOSTnUPP3/35024.61wnormalPOSTnPPP2/35722.59bnormalPOSTnUPN3/34022.58wnormalPREyUNN3/35422.41wnormalPOSTnUNP1/35522.76wnormalPOSTnUPP2/35023.71wnormalPOSTnNPU2/33823.53wnormalPREnUPN3/34723.83wnormalPREnNNN1/33924.06wnormalPREnUPP2/36124.69wnormalPOSTyUPN2/34723.34wnormalPREnPNP3/33819.1wnormalPREnNPP2/34422.27wnormalPREnNPP1/34923.05wnormalPREnNPN3/35724anormalPOSTnNNP2/34524.45wnormalPERInNPP3/34122.06anormalPREnNPP3/33820.4anormalPREnPPP1/34124.06bnormalPREnNPP1/37224.91wnormalPOSTnNPN3/33323.88wnormalPREnNNN3/34223.74wnormalPREnNNP2/34519.72wnormalPREnNPN1/34419.92wnormalPREyPNarrayexpress_sid3Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted...21750966E-GEOD-24185/profile/8773/arrayexpressuploader10103adipocytebodybreastbreast cancercancercelldiseaseinsulinobesityDec.12, 2014Falsegene-transcription-signature-of-obesity-in-breastE-GEOD-24185_A-AFFY-33Gene transcription signature of obesity in breast cancerJun.18, 2014Obesity is thought to contribute to worse disease outcome in breast cancer as a result of increased levels of adipocyte-secreted endocrine factors, insulin, and insulin-like growth factors (IGFs) that accelerate tumor cell proliferation and impair treatment response. We examined the effects of patient obesity on primary breast tumor gene expression, by profiling transcription of a set of tumors for which the patients’ body mass index (BMI) was ascertained. Sample profiles were stratified according to patients’ obesity phenotype defined as normal (BMI <25), overweight (BMI 25-29.9), or obese (BMI>30). Widespread alterations in gene expression were evident in breast tumors from obese patients as compared to tumors from other patients, allowing us to define an obesity-associated cancer transcriptional signature of 662 genes. Keywords: two group comparison Primary breast tumor specimens were obtained from patients. Study volunteers completed questionnaires used to define historically normal (BMI<=24.9), overweight (BMI 25-29.9), or obese (BMI>=30) patient categories according to established WHO criteria.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24185humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-24185/samples/