ArrayExpress Uploaderarrayexpress_sidmousecontrolHGF/SF1anti-??5??1 integrin antibody (clone BMB5)controlHGF/SF1anti-??5??1 integrin antibody (clone BMB5)controlHGF/SF1anti-??5??1 integrin antibody (clone BMB5)850208Cells treated with a specific antibody against α5β1 integrin exhibited cell spreading and scattering, over-expression of liver...E-GEOD-23853/profile/8773/arrayexpressuploader19cellchromatinintegrinliverDec.12, 2014FalseE-GEOD-23853_A-AFFY-36functional-blockade-of-51-integrin-induces-scatterFunctional blockade of α5β1 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cellsNov.24, 2014Cells treated with a specific antibody against α5β1 integrin exhibited cell spreading and scattering, over-expression of liver stem/progenitor cell markers and activation of the ERK1/2 and p38 MAPKs signaling cascades, in a similar manner to the process triggered by HGF/SF1 stimulation. Gene expression profiling revealed marked transcriptional changes of genes involved in cell adhesion and migration, as well as genes encoding chromatin remodeling factors. These responses were accompanied by conspicuous spatial reorganization of centromeres, while integrin genes conserved their spatial positioning in the interphase nucleus. Untreated cells versus HGF/SF1 treated or α5β1 integrin-mediated cell migrationhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23853http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23853/samples/