{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "mouse", "factors": [{"GSM588070": {"AGENT": "control"}}, {"GSM58807": {"AGENT": "HGF/SF1"}}, {"GSM588072": {"AGENT": "anti-??5??1 integrin antibody (clone BMB5)"}}, {"GSM588070": {"AGENT": "control"}}, {"GSM58807": {"AGENT": "HGF/SF1"}}, {"GSM588072": {"AGENT": "anti-??5??1 integrin antibody (clone BMB5)"}}, {"GSM588070": {"AGENT": "control"}}, {"GSM58807": {"AGENT": "HGF/SF1"}}, {"GSM588072": {"AGENT": "anti-??5??1 integrin antibody (clone BMB5)"}}], "id": 8502, "pop_total": 0, "platform": 8, "summary_wrapped": "Cells treated with a specific antibody against \u03b15\u03b21 integrin exhibited cell spreading and scattering, over-expression of liver...", "geo_gse_id": "E-GEOD-23853", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 9, "tags": ["cell", "chromatin", "integrin", "liver"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-23853_A-AFFY-36", "slug": "functional-blockade-of-51-integrin-induces-scatter", "geo_gds_id": "", "name": "Functional blockade of \u03b15\u03b21 integrin induces scattering and genomic landscape remodeling of hepatic progenitor cells", "created": "Nov.24, 2014", "summary": "Cells treated with a specific antibody against \u03b15\u03b21 integrin exhibited cell spreading and scattering, over-expression of liver stem/progenitor cell markers and activation of the ERK1/2 and p38 MAPKs signaling cascades, in a similar manner to the process triggered by HGF/SF1 stimulation. Gene expression profiling revealed marked transcriptional changes of genes involved in cell adhesion and migration, as well as genes encoding chromatin remodeling factors. These responses were accompanied by conspicuous spatial reorganization of centromeres, while integrin genes conserved their spatial positioning in the interphase nucleus. Untreated cells versus HGF/SF1 treated or \u03b15\u03b21 integrin-mediated cell migration", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23853", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23853/samples/"}