{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "species": "human", "factors": [{"GSM587958 1": {}}, {"GSM587959 1": {}}, {"GSM587960 1": {}}, {"GSM587961 1": {}}, {"GSM587962 1": {}}, {"GSM587963 1": {}}, {"GSM587964 1": {}}, {"GSM587965 1": {}}], "id": 3792, "pop_total": 0, "platform": 4, "summary_wrapped": "Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER...", "geo_gse_id": "E-GEOD-23849", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 8, "tags": ["cancer", "cell", "class", "endoplasmic reticulum", "lymphoma", "mantle cell lymphoma", "membrane", "multiple myeloma", "myeloma", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-23849_A-AFFY-44", "slug": "the-erad-inhibitor-eeyarestatin-i-is-a-bifunctiona", "geo_gds_id": "", "name": "The ERAD inhibitor Eeyarestatin I is a bifunctional compound with an ER localizing domain and a p97/VCP inhibitory group", "created": "Sep.15, 2014", "summary": "Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death for cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug approved for treatment of multiple myeloma and Mantle cell lymphoma. We recently reported that the ERAD inhibitor Eeyarestatin I (EerI) also disturbs ER homeostasis and has anti-cancer activities resembling that of Bortezomib. Our findings reveal a class of bifunctional chemical agents that can preferentially inhibit membrane-bound p97 to disrupt ER homeostasis and induce tumor cell death. These results also suggest that the AAA ATPase p97 may be a potential drug target for cancer therapy. Cells were treated with EerI, CBU-028, or 5-NA each at 10uM in duplicates for 10h", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23849", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23849/samples/"}