Dataset: DNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma

We performed DNA methylation (HELP array) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by...

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We performed DNA methylation (HELP array) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as "germinal center B cell-like" (GCB) and "activated B cell-like" (ABC) DLBCL were assigned to the 69 DLBCL cases. Then, the supervised analysis using HELP data revealed strikingly different DNA promoter methylation patterns in the two molecular DLBCL subtypes. These data provide epigenetic evidence that the DLBCL subtypes are distinct diseases that utilize different oncogenic pathways. The retrospective study included RNA and DNA extracted from 69 clinical samples. This submission represents the gene expression component of the study.

Species:: human
Samples:: 69
Source:: E-GEOD-23501
PubMed:: 20610814
Updated:: Dec.12, 2014
Registered:: Sep.15, 2014

Factors: (via ArrayExpress)

Sample	STATUS	ORGANISM PART	EXPRESSION	AGE	SEX	PFS	TXPRIMARY	SURVIVAL (YEARS)	PATHOLOGY	OS	STAGE
GSM575635	free of disease after initial treatment	lymph node	GCB	55	M	alive	CHOP6-RITU	5.13	DLBC	alive	2A
GSM575636	free of disease after initial treatment	lymph node	ABC	54	F	alive	CHOP6-RITU	5.62	DLBC	alive	3A
GSM575637	free of disease after initial treatment	lymph node	ABC	77	M	alive	CVPP1-DOXO-CYCL5-RITU	5.96	DLBC	alive	3BE
GSM575638	lymphoma death	lymph node	GCB	62	M	dead	CHOP2-RITU	0.73	DLBC	dead	1A
GSM575639	free of disease after initial treatment	lymph node	GCB	73	F	alive	CHOP6-RITU	5.48	DLBC	alive	not specified
GSM575640	free of disease after treatment for first relapse	lymph node	ABC	72	M	dead	CHOP6-RITU-RAD	7.32	DLBC	alive	4B
GSM57564	lymphoma death	lymph node	GCB	57	M	dead	CHOP8-RITU	0.63	DLBC	dead	3AE
GSM575642	free of disease after initial treatment	lymph node	ABC	66	M	alive	CHOP4-RITU	2.48	DLBC	alive	1A
GSM575643	lymphoma death	lymph node	NC	73	M	dead	CHOP3-RITU-RAD	1.29	COMPOSITE (>50% DLBCL, remaining FL)	dead	2A
GSM575644	free of disease after initial treatment	lymph node	GCB	56	M	alive	CHOP6-RITU	5.08	DLBC	alive	4A
GSM575645	free of disease after initial treatment	GI	GCB	53	M	alive	CHOP6-RITU	2.87	DLBC	alive	not specified
GSM575646	free of disease after initial treatment	lymph node	GCB	77	M	alive	CHOP6-RITU	5.37	DLBC	alive	4B
GSM575647	free of disease after initial treatment	tonsil	NC	23	M	alive	CHOP3-RITU-RAD	5.07	DLBC	alive	2AE
GSM575648	lymphoma death	lymph node	ABC	67	M	dead	CHOP-RITU	0.94	DLBC	dead	4A
GSM575649	lymphoma death	spleen	NC	21	M	dead	CHOP2-RITU-SPLE	0.4	DLBC	dead	4B
GSM575650	death unrelated	lymph node	GCB	80	F	alive	CHOP(CEOP)1-RITU	3.2	DLBC	dead	1A
GSM57565	lymphoma death	lymph node	ABC	71	F	dead	CHOP-RITU	0.03	DLBC	dead	2AE
GSM575652	free of disease after initial treatment	spleen	NC	73	M	alive	SPLE-CHOP-RITU-RAD	3.76	DLBC	alive	2BE
GSM575653	free of disease after initial treatment	lymph node	GCB	59	M	alive	CHOP3-RITU-RAD	3.27	DLBC	alive	2A
GSM575654	free of disease after initial treatment	lymph node	NC	73	M	alive	CHOP8-RITU-G3139	2.69	DLBC	alive	3A
GSM575655	lymphoma death	lymph node	ABC	49	M	dead	CHOP1-RITU	0.16	DLBC	dead	3AE
GSM575656	free of disease after initial treatment	spleen	GCB	56	M	alive	CHOP6-RITU	2.86	DLBC	alive	4B
GSM575657	free of disease after initial treatment	thyroid	GCB	57	F	alive	CHOP3-RITU-RAD	2.66	DLBC	alive	1AE
GSM575658	free of disease after initial treatment	GI	GCB	92	F	alive	CHOP5-RITU	2.19	DLBC	alive	2BE
GSM575659	free of disease after treatment for first relapse	ENT	ABC	51	M	dead	CHOP6-RITU	2.47	DLBC	alive	2AE
GSM575660	free of disease after initial treatment	lymph node	NC	16	F	alive	CHOP4-RITU	2.5	DLBC	alive	1A
GSM57566	free of disease after initial treatment	lymph node	GCB	52	F	alive	CHOP6-RITU-RITUMAIN	1.84	DLBC	alive	4A
GSM575662	free of disease after initial treatment	lymph node	GCB	22	M	alive	CHOP4-RITU	1.82	DLBC	alive	2A
GSM575663	lymphoma death	lymph node	GCB	82	F	dead	FLUD1	0.28	DLBC	dead	3A
GSM575664	Receiving treatment for first relapse	lymph node	GCB	47	M	dead	CHOP6-RITU	2.37	DLBC	alive	4B
GSM575665	free of disease after initial treatment	lymph node	GCB	80	F	alive	CHOP3-RITU-RAD	5.82	DLBC	alive	3A
GSM575666	free of disease after initial treatment	lymph node	GCB	79	M	alive	CHOP6-RITU	2.67	DLBC	alive	2A
GSM575667	lymphoma death	lymph node	ABC	57	M	dead	CHOP6-RITU	0.9	DLBC	dead	4B
GSM575668	free of disease after initial treatment	lymph node	GCB	60	M	alive	CHOP8-RITU-RAD	5.11	DLBC	alive	2B
GSM575669	free of disease after initial treatment	lymph node	GCB	68	F	alive	CHOP7-RITU	4.49	DLBC	alive	3B
GSM575670	free of disease after initial treatment	lymph node	GCB	66	M	alive	CHOP6-RITU	2.81	DLBC	alive	3A
GSM57567	free of disease after initial treatment	lymph node	GCB	69	M	alive	CHOP-RITU-ABVD	4.12	DLBC	alive	4B
GSM575672	free of disease after initial treatment	lymph node	ABC	84	M	alive	CHOP6-RITU	2.74	DLBC	alive	3A
GSM575673	toxic death	lymph node	ABC	73	F	dead	CHOP4-RITU	0.52	DLBC	dead	2A
GSM575674	free of disease after initial treatment	lymph node	GCB	19	M	alive	CHOP6-RITU	2.61	DLBC	alive	1AE
GSM575675	lymphoma death	lymph node	ABC	81	M	dead	CHOP6-RITU-RAD	1.41	DLBC	dead	3B
GSM575676	free of disease after treatment for first relapse	spleen	GCB	65	M	dead	CHOP6-RITU	4.29	DLBC	alive	4B
GSM575677	free of disease after initial treatment	lymph node	GCB	62	M	alive	CHOP3-RITU-RAD	4.49	DLBC	alive	2A
GSM575678	free of disease after initial treatment	lymph node	GCB	50	M	alive	CHOP3-RITU-RAD	3.67	DLBC	alive	1A
GSM575679	lymphoma death	gastric	NC	78	M	dead	DOXO-CYCL2-RITU	0.62	DLBC	dead	4B
GSM575680	free of disease after initial treatment	GI	GCB	68	M	alive	CHOP6-RITU	1.55	DLBC	alive	not specified
GSM57568	free of disease after initial treatment	lymph node	GCB	61	M	alive	CHOP6-RITU	2.3	DLBC	alive	4B
GSM575682	free of disease after initial treatment	lymph node	NC	65	M	alive	CHOP7-RITU	1.88	DLBC	alive	2A
GSM575683	With disease, after initial treatment	lymph node	ABC	54	M	alive	CYCL1-CHOP6-RITU	1.65	DLBC	alive	3A
GSM575684	free of disease after initial treatment	breast	NC	62	F	alive	CHOP3-RITU-RAD	1.97	DLBC	alive	1AE
GSM575685	free of disease after initial treatment	lymph node	ABC	50	M	alive	CHOP6-RITU	1.78	DLBC	alive	not specified
GSM575686	free of disease after initial treatment	lymph node	ABC	60	M	alive	CHOP6-RITU	1.63	DLBC	alive	3A
GSM575687	With disease, after initial treatment	ENT	GCB	80	F	alive	CVP1-RITU,CHOP5-RITU	1.74	DLBC	alive	3AE
GSM575688	free of disease after initial treatment	lymph node	GCB	68	F	alive	CHOP4-RITU	0.93	DLBC	alive	1A
GSM575689	free of disease after initial treatment	lymph node	GCB	76	M	alive	CHOP5-RITU	1.25	DLBC	alive	3A
GSM575690	free of disease after initial treatment	lymph node	ABC	45	M	alive	CHOP-RITU	0.68	DLBC	alive	2B
GSM57569	free of disease after initial treatment	lymph node	ABC	69	F	alive	CHOP4-RITU	0.99	DLBC	alive	2AE
GSM575692	free of disease after initial treatment	lymph node	GCB	68	F	alive	CHOP6-RITU	0.43	DLBC	alive	3B
GSM575693	With disease, after initial treatment	lymph node	GCB	49	F	alive	CHOP4-RITU	1.54	DLBC	alive	3A
GSM575694	free of disease after initial treatment	lymph node	GCB	76	M	alive	CHOP4-RITU	0.99	DLBC	alive	1A
GSM575695	free of disease after initial treatment	lymph node	GCB	78	M	alive	CHOP8-RITU	1.02	COMPOSITE (>50% DLBCL, remaining FL)	alive	2A
GSM575696	free of disease after initial treatment	testis	ABC	67	M	alive	CHOP6-RITU-RAD	1.14	DLBC	alive	2AE
GSM575697	free of disease after initial treatment	lymph node	GCB	77	M	alive	CHOP6-RITU	0.99	DLBC	alive	2B
GSM575698	free of disease after initial treatment	lymph node	GCB	68	M	alive	CHOP4-RITU	0.74	DLBC	alive	1A
GSM575699	free of disease after initial treatment	lymph node	GCB	67	M	alive	CHOP6-RITU-RAD	0.56	COMPOSITE (>50% DLBCL, remaining FL)	alive	2A
GSM575700	free of disease after initial treatment	lymph node	GCB	58	M	alive	CHOP6-RITU	0.73	DLBC	alive	2A
GSM57570	free of disease after initial treatment	lymph node	GCB	58	M	alive	CHOP6-RITU-RITUMAIN	0.79	COMPOSITE (>50% DLBCL, remaining FL)	alive	3B
GSM575702	free of disease after initial treatment	lymph node	ABC	73	M	alive	CHOP4-RITU	0.64	DLBC	alive	1A
GSM575703	not specified	lymph node	ABC	57	F	dead	CHOP6	10.29	DLBC	alive	3A