{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3765, "factors": [{"GSM573357": {"STIMULUS": "None"}}, {"GSM573357": {"STIMULUS": "None"}}, {"GSM573357": {"STIMULUS": "None"}}, {"GSM573360": {"STIMULUS": "LPS 6 hr"}}, {"GSM573360": {"STIMULUS": "LPS 6 hr"}}, {"GSM573360": {"STIMULUS": "LPS 6 hr"}}, {"GSM573363": {"STIMULUS": "IL10/dexamethasone 24 hr"}}, {"GSM573363": {"STIMULUS": "IL10/dexamethasone 24 hr"}}, {"GSM573363": {"STIMULUS": "IL10/dexamethasone 24 hr"}}, {"GSM573366": {"STIMULUS": "IL10/dexamethasone 24 hr, then LPS 6hr"}}, {"GSM573366": {"STIMULUS": "IL10/dexamethasone 24 hr, then LPS 6hr"}}, {"GSM573366": {"STIMULUS": "IL10/dexamethasone 24 hr, then LPS 6hr"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Little is known about the early transcriptional events in innate immune signaling in immature and tolerogenic monocyte-derived dendritic...", "pubmed_id": 21708028, "geo_gse_id": "E-GEOD-23371", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 12, "tags": ["dendritic", "immune system", "monocyte"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-23371_A-AFFY-44", "slug": "transcriptomes-of-monocyte-derives-dcs-stimulated", "geo_gds_id": "", "name": "Transcriptomes of monocyte-derives DCs stimulated with various compounds", "created": "Sep.15, 2014", "summary": "Little is known about the early transcriptional events in innate immune signaling in immature and tolerogenic monocyte-derived dendritic cells (DCs), the professional antigen-presenting cells of our immune system. TLR ligands usually induce a proinflammatory transcriptional response, whereas IL10 and/or dexamethasone induce a more tolerogenic phenotype. We used Affymetrix microarrays to obtain detailed information underlying pro- and anti-inflammatory transcriptional responsesand transcriptional networks in DCs A pilot experiment was performed in which monocyte-derived DCs were either treated with TLR4 ligand LPS, or IL10 and dexamethason. Furthermore, IL10/dexamethason treated cells were also stimulated with LPS for an additional 6 hr. All samples were then subjected to global gene expression analysis using Affymetrix technology.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23371", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23371/samples/"}