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(1-YES)": 0, "AGE IN YEARS": 35, "USED IN FL/EMZL VS HEALTHY COMPARISON (1-YES)": 1, "USED IN MGUS VS HEALTHY COMPARISON (1-YES)": 0}}, {"GSM571758": {"DISEASE STATE": "healthy", "USED IN CLL VS HEALTHY COMPARISON (1-YES)": 0, "AGE IN YEARS": 49, "USED IN FL/EMZL VS HEALTHY COMPARISON (1-YES)": 1, "USED IN MGUS VS HEALTHY COMPARISON (1-YES)": 1}}, {"GSM571759": {"DISEASE STATE": "FL", "USED IN CLL VS HEALTHY COMPARISON (1-YES)": 0, "AGE IN YEARS": 68, "USED IN FL/EMZL VS HEALTHY COMPARISON (1-YES)": 1, "USED IN MGUS VS HEALTHY COMPARISON (1-YES)": 0}}, {"GSM571760": {"DISEASE STATE": "healthy", "USED IN CLL VS HEALTHY COMPARISON (1-YES)": 0, "AGE IN YEARS": 36, "USED IN FL/EMZL VS HEALTHY COMPARISON (1-YES)": 1, "USED IN MGUS VS HEALTHY COMPARISON (1-YES)": 0}}], "id": 3759, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone....", "pubmed_id": 21270444, "geo_gse_id": "E-GEOD-23293", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 5, "sample_count": 41, "tags": ["cell", "cll", "compartment", "cytokine", "hepatitis", "hepatitis b", "immune system", "intermediate", "lymphoma", "mgus", "myeloma", "peripheral", "proximal"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-23293_A-AFFY-44", "slug": "definition-and-characterization-of-the-systemic-t", "geo_gds_id": "", "name": "Definition and characterization of the systemic T cell dysregulation in untreated indolent B cell lymphoma and very early CLL", "created": "Sep.15, 2014", "summary": "Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone. Conversely, systemic lymphomas, especially myeloma and CLL, are associated with clinical immunodeficiency. This prospective controlled study demonstrates substantially reduced circulating T helper cells, predominantly naive CD4+ cells, in patients with non-leukemic follicular and extranodal marginal zone lymphomas, but not in monoclonal gammopathy and early CLL. These numerical changes were correlated with a preactivated phenotype, hyperreactivity in vitro, presenescence, and a Th2 shift of peripheral T helper cells. No prominent alterations were found in the regulatory T cell compartment. Gene expression profiling of in vitro-stimulated CD4+ cells revealed an independent second alteration of T helper cell physiology which was most pronounced in early CLL but also detectable in FL/eMZL. This pattern consisted of downregulation of proximal and intermediate T-cell receptor signaling cascades and globally reduced cytokine secretion. Both types of T cell dysfunction may contribute to significant immunodeficiency in non-leukemic indolent B-cell lymphomas as demonstrated by refractoriness to hepatitis B vaccination. The precise definition of systemic T cell dysfunction serves as the basis to study its prognostic impact, its relationship to the established influence of the lymphoma microenvironment, and its therapeutic manipulation 8 samples from FL/eMZL patients, 7 samples from CLL patients, 5 samples of MGUS patients, 5 MALT, 16 healthy controls", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23293", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23293/samples/"}