ArrayExpress Uploader03756PRF1 protective haplotype: AGA/AGAPRF1 protective haplotype: AGA/AGAPRF1 protective haplotype: AGA/AGAPRF1 protective haplotype: AGA/AGAPRF1 risk haplotype: AGG/GAAPRF1 risk haplotype: AGG/GAAPRF1 risk haplotype: AGG/GAAPRF1 risk haplotype: AGG/GAAPRF1 risk haplotype: AGG/GAAPRF1 risk haplotype: AGG/GAAarrayexpress_sid4A genetic study of the PRF1 gene has shown association of several polymorphisms with multiple sclerosis (MS). Haplotype analysis...20921521E-GEOD-23205/profile/8773/arrayexpressuploader110cellmultiple sclerosisppmsDec.12, 2014Falsetranscription-profiling-of-peripheral-blood-from-pE-GEOD-23205_A-AFFY-44Transcription profiling of peripheral blood from patients with primary progressive multiple sclerosis to compare risk and protective PRF1 haplotypesSep.15, 2014A genetic study of the PRF1 gene has shown association of several polymorphisms with multiple sclerosis (MS). Haplotype analysis identified risk haplotypes strongly associated with male patients having the primary-progressive form of MS (PPMS). Gene expression microarrays were performed in 10 male PPMS patients carrying the risk (n=6) and protective haplotypes (n=4) in order to identify pathways associated with the risk haplotypes. Pathway analysis revealed overrepresentation of the cell killing gene ontology category among down-regulated genes in patients carrying risk haplotypes compared with patients carrying protective haplotypes. Number of samples analyzed: 10 Protective haplotype samples: UOM982, EMA1473, MMC-998, CDP1842 Risk haplotype samples: UUS1554, RAU1550, RPS1011, AGS1013, PFB1530, MGA1014http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23205humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23205/samples/