{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 3756, "factors": [{"GSM570896": {"genotype": "PRF1 protective haplotype: AGA/AGA"}}, {"GSM570896": {"genotype": "PRF1 protective haplotype: AGA/AGA"}}, {"GSM570896": {"genotype": "PRF1 protective haplotype: AGA/AGA"}}, {"GSM570896": {"genotype": "PRF1 protective haplotype: AGA/AGA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}, {"GSM570900": {"genotype": "PRF1 risk haplotype: AGG/GAA"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "A genetic study of the PRF1 gene has shown association of several polymorphisms with multiple sclerosis (MS). Haplotype analysis...", "pubmed_id": 20921521, "geo_gse_id": "E-GEOD-23205", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 10, "tags": ["cell", "multiple sclerosis", "ppms"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-of-peripheral-blood-from-p", "geo_id_plat": "E-GEOD-23205_A-AFFY-44", "name": "Transcription profiling of peripheral blood from patients with primary progressive multiple sclerosis to compare risk and protective PRF1 haplotypes", "created": "Sep.15, 2014", "summary": "A genetic study of the PRF1 gene has shown association of several polymorphisms with multiple sclerosis (MS). Haplotype analysis identified risk haplotypes strongly associated with male patients having the primary-progressive form of MS (PPMS). Gene expression microarrays were performed in 10 male PPMS patients carrying the risk (n=6) and protective haplotypes (n=4) in order to identify pathways associated with the risk haplotypes. Pathway analysis revealed overrepresentation of the cell killing gene ontology category among down-regulated genes in patients carrying risk haplotypes compared with patients carrying protective haplotypes. Number of samples analyzed: 10 Protective haplotype samples: UOM982, EMA1473, MMC-998, CDP1842 Risk haplotype samples: UUS1554, RAU1550, RPS1011, AGS1013, PFB1530, MGA1014", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23205", "species": "human", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23205/samples/"}