BioGPS
  • Home
  • Help
  • Plugins
  • Datasets
  • Sign Up
  • Login
Examples: Gene Symbol(s), Gene Ontology, Splicing plugins, Melanoma datasets
advanced
Home › Dataset Library › Comparative Effects of Statins on Murine Cardiac Gene Expression Profiles in Normal Mice

Dataset: Comparative Effects of Statins on Murine Cardiac Gene Expression Profiles in Normal Mice

Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs...

Registered by ArrayExpress Uploader
View Dataset

Recent clinical data suggest that the efficacy of statin treatment in patients with heart failure varies depending on the drugs administered. Therefore, the present study was undertaken to compare murine cardiac gene expression following treatment with four different statins. Statins directly regulated cardiac gene expression in a drug-specific manner in mice. The influence of each statin on the cardiac mRNA expression of various genes, including several genes that might be involved in the development of cardiac disease, was not a general effect of this class of drugs. Male C57BL/6J mice (n = 20) were treated with or without a statin (pitavastatin calcium, pravastatin sodium, rosuvastatin calcium, or atorvastatin calcium hydrate) (n = 4 in each group) for four weeks. Total RNA was isolated from the left ventricle of each animal. The fragmented and labeled amplified cDNA was hybridized to a GeneChip Mouse Genome 430 2.0 Array (Affymetrix). Data and statistical analysis were performed with GeneSpring GX version 11.0 software (Agilent Technologies).

Species:
mouse

Samples:
20

Source:
E-GEOD-23101

PubMed:
23524094

Updated:
Dec.12, 2014

Registered:
Nov.11, 2014


Factors: (via ArrayExpress)
Sample COMPOUND
GSM569325 control
GSM569325 control
GSM569325 control
GSM569325 control
GSM569329 pitavastatin (Livalo)
GSM569329 pitavastatin (Livalo)
GSM569329 pitavastatin (Livalo)
GSM569329 pitavastatin (Livalo)
GSM569333 pravastatin (Mevalotin)
GSM569333 pravastatin (Mevalotin)
GSM569333 pravastatin (Mevalotin)
GSM569333 pravastatin (Mevalotin)
GSM569337 rosuvastatin (Crestor)
GSM569337 rosuvastatin (Crestor)
GSM569337 rosuvastatin (Crestor)
GSM569337 rosuvastatin (Crestor)
GSM56934 atorvastatin (Lipitor)
GSM56934 atorvastatin (Lipitor)
GSM56934 atorvastatin (Lipitor)
GSM56934 atorvastatin (Lipitor)

Tags

  • class
  • disease
  • genome
  • heart
  • left
  • left ventricle
  • ventricle

Other Formats

JSON    XML
  • About
  • Blog
  • Help
  • FAQ
  • Downloads
  • API
  • iPhone App
  • Email updates
© 2022 The Scripps Research Institute. All rights reserved. (ver 94eefe6 )
  • Terms of Use