ArrayExpress Uploader03751control1vehicleRAR and RXR agonist19-cis retinoic acidRXR agonist1LG268PPARg agonist1rosiglitazonePPARd agonist1GW1516LXR agonist1GW3965control2vehicleRAR and RXR agonist29-cis retinoic acidRXR agonist2LG268PPARg agonist2rosiglitazonePPARd agonist2GW1516LXR agonist2GW3965control3vehicleRAR and RXR agonist39-cis retinoic acidRXR agonist3LG268PPARg agonist3rosiglitazonePPARd agonist3GW1516LXR agonist3GW3965control4vehicleRAR agonist4AM580VDR agonist41,25-dihydroxyvitamin D3control5vehicleRAR agonist5AM580VDR agonist51,25-dihydroxyvitamin D3control6vehicleRAR agonist6AM580VDR agonist61,25-dihydroxyvitamin D3arrayexpress_sid4CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or...20861222E-GEOD-23073/profile/8773/arrayexpressuploader327dendriticmonocyteDec.12, 2014Falsetranscriptome-profiling-of-genes-regulated-by-rxrE-GEOD-23073_A-AFFY-44Transcriptome profiling of genes regulated by RXR and its partners in monocyte-derived dendritic cellsSep.15, 2014CD14+ human monocytes differentiating into DCs in the presence of IL4 and GM-CSF were treated with agonists for RXR and its partners or vehicle 18 hours after plating (experiment with RXR and permissive partners, donor 1-3) or 14 hours after plating (experiment with nonpermissive partners, donor 4-6). Cells were harvested 12 hours thereafter. Experiments were performed in biological triplicates representing samples from three different donors.  In this study all probable RXR-signaling pathways induced by agonists for RXR, LXRs, PPARs, RAR and VDR were identified in differentiating human monocyte-derived dendritic cells. In the experiments, differentiating dendritic cells were treated for 12 hours with one of the following compounds (ligands): vehicle (DMS:EtOH 1:1) LG268 (RXR agonist) 9-cis retinoic acid (9cisRA, agonist of RAR and RXR) GW3965 (LXRalpha/beta panagonist) rosiglitazone (RSG, PPARgamma agonist)  GW1516 (PPARdelta agonist) AM580 (RARalpha agonist) 1,25-dihydroxyvitamin D3 (VDR agonist)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23073humanhttp://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23073/samples/