{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6159, "factors": [{"GSM567848 1": {}}, {"GSM567849 1": {}}, {"GSM567850 1": {}}, {"GSM567851 1": {}}, {"GSM567852 1": {}}, {"GSM567853 1": {}}, {"GSM567854 1": {}}, {"GSM567855 1": {}}, {"GSM567856 1": {}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "IL-4d2 is a natural splice variant of IL-4 which lacks the region encoded by the second exon. Numerous recent reports suggested that the...", "pubmed_id": 21285395, "geo_gse_id": "E-GEOD-23016", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 9, "tags": ["cytokine", "exon", "interleukin", "interleukin-4"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "alternatively-spliced-variants-of-interleukin-4-pr", "geo_id_plat": "E-GEOD-23016_A-AFFY-45", "name": "Alternatively Spliced Variants of Interleukin-4 Promote Inflammation Differentially", "created": "Nov.11, 2014", "summary": "IL-4d2 is a natural splice variant of IL-4 which lacks the region encoded by the second exon. Numerous recent reports suggested that the expression levels of IL-4d2 change in various diseases, especially those with pulmonary involvement, but the effects of IL-4d2 on the lungs in vivo have never been studied. Replication-deficient adenovirus-mediated gene delivery of mouse IL-4d2 to mouse lungs in vivo was used, and the effects compared with similar adenoviral delivery of mouse IL-4 or with infection with a NULL viral construct. The objective was to determine whether full-length wild-type Interleukin-4 encoded by exons 1-4 (IL-4) and alternatively spliced variant econded by exons 1,3, and 4 (IL-4d2) differentially affect gene expression in the lungs in vivo. The results show that IL-4d2 and IL-4 affected global gene expression differentially.  Keywords: Comparative analysis of gene delivery of alternative splice variants in vivo There were three mice overexpressing mouse IL-4 in their lungs, three mice overexpressing mouse IL-4d2 in their lungs, and three mice similarly infected with control AdV-NULL virus not encoding a cytokine.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23016", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-23016/samples/"}