{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6153, "factors": [{"GSM567345": {"CELL TYPE": "CD8aa Tregs"}}, {"GSM567345": {"CELL TYPE": "CD8aa Tregs"}}, {"GSM567345": {"CELL TYPE": "CD8aa Tregs"}}, {"GSM567348": {"CELL TYPE": "OT-1 CD8aa+TCRab+ T cells"}}, {"GSM567348": {"CELL TYPE": "OT-1 CD8aa+TCRab+ T cells"}}, {"GSM567348": {"CELL TYPE": "OT-1 CD8aa+TCRab+ T cells"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "To better understand the function of CD8aa Tregs, we have recently characterized several CD8aa+TCRab+ T cell clones and lines that are...", "pubmed_id": 21889557, "geo_gse_id": "E-GEOD-22985", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cell", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "global-expression-profiling-of-peripheral-qa-1-cla", "geo_id_plat": "E-GEOD-22985_A-AFFY-45", "name": "Global expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire", "created": "Nov.11, 2014", "summary": "To better understand the function of CD8aa Tregs, we have recently characterized several CD8aa+TCRab+ T cell clones and lines that are physiologically primed and are involved in recovery and protection from EAE (REF). In this report, we present a comparison of global gene expression patterns in CD8aa Tregs versus OT-1 CD8aa+TCRab+ T cells. The results of microarray data analysis are confirmed by real-time PCR and flow cytometry for better accuracy and phenotype expression. Our study reveals a unique gene signature in the CD8aa Tregs, including enhanced expression of several inhibitory molecules associated with the maintenance of peripheral T cell homeostasis. The identification of differentially expressed molecules by CD8aa Tregs should facilitate future functional studies in this area. gene expression patterns in CD8aa Tregs versus OT-1 CD8aa+TCRab+ T cells", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22985", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22985/samples/"}