{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM564797 1": {}}, {"GSM564798 1": {}}, {"GSM564799 1": {}}, {"GSM564800 1": {}}], "id": 3739, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Coordinated regulation of the ubiquitin-proteasome system is crucial for the cell to adjust its protein degradation capacity to changing...", "geo_gse_id": "E-GEOD-22853", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 0, "sample_count": 4, "tags": ["cell", "protein"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-human-eahy926-cells-in-respon", "geo_id_plat": "E-GEOD-22853_A-AFFY-44", "name": "Expression data from human Ea.hy926 cells in response to epoxomicin and in dependency of TCF11 presence", "created": "Sep.15, 2014", "summary": "Coordinated regulation of the ubiquitin-proteasome system is crucial for the cell to adjust its protein degradation capacity to changing proteolytic requirements. The transcription factor TCF11 has been identified as a  regulator for 26S-proteasome formation in human cells to compensate for reduced proteolytic activity. To expand the current knowledge of other UPS-related TCF11 target genes in response to epoxomicin, we performed microarray analyses of cells exposed to epoxomicin and with or without depletion of TCF11.  Keywords: siRNA depletion Human Ea.hy926 cells were harvested 24 hours following treatment with 10nM epoxomicin or DMSO as a solvent control and with transfection of control siRNA or TCF11-specific siRNA for RNA extraction and hybridization on Affymetrix microarrays.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22853", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22853/samples/"}