ArrayExpress Uploader0mouseskeletal muscle precursor cells (SMPs)skeletal muscle precursor cells (SMPs)skeletal muscle precursor cells (SMPs)skeletal muscle precursor cells (SMPs)CD45-MAC1-TER119-Sca1-CXCR4- cellsCD45-MAC1-TER119-Sca1-CXCR4- cellsCD45-MAC1-TER119-Sca1-CXCR4- cellsCD45-MAC1-TER119-Sca1-CXCR4- cellsnon-myogenic progenitors (ScaPCs)non-myogenic progenitors (ScaPCs)non-myogenic progenitors (ScaPCs)non-myogenic progenitors (ScaPCs)6141arrayexpress_sid6This work examines sarcoma formation within discrete subsets of KRAS(G12V)-expressing p16p19null myogenic and mesenchymal cells found...E-GEOD-22841/profile/8773/arrayexpressuploader112cancercellgenomemusclesarcomasatellite cellDec.12, 2014Falsediscrete-subsets-of-myogenic-and-mesenchymal-precuE-GEOD-22841_A-AFFY-45Discrete subsets of myogenic and mesenchymal precursors give rise to soft tissue sarcomas of distinct lineage differentiationNov.11, 2014This work examines sarcoma formation within discrete subsets of KRAS(G12V)-expressing p16p19null myogenic and mesenchymal cells found normally in skeletal muscle. We show that prospectively isolated skeletal muscle precursor cells (SMPs) within the satellite cell pool can serve as cancer cells-of-origin for mouse rhabdomyosarcomas (soft tissue sarcomas with features of myogenic differentiation). Alternatively, non-myogenic progenitors (ScaPCs) induce sarcomas lacking myogenic differentiation markers. We used Affymetrix whole mouse genome 430 2.0 microarrays to gain deeper insights into the molecular underpinnings of the three types of KRAS; p16p19null mouse soft-tissue sarcomas (originating from SMPs, ScaPCs and CD45-MAC1-TER119-Sca1-CXCR4- cells). Four replicates of each type.http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22841http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22841/samples/