{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM564240": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564240": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564240": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564243": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564243": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564243": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564246": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564246": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564246": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total retinas", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564249": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564249": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564249": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564252": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564252": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564252": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564255": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564255": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564255": {"DEVELOPMENTAL STAGE": "Postnatal day 4 (before retinal ganglion cell segregation in lateral geniculate nucleus)", "TISSUE": "left and right total lateral geniculate nucleus (LGN)", "MOUSE": "  ", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564258": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "1542", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564259": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "1543", "MUTANT ALLELE": "Picciotto", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Picciotto mutant)"}}, {"GSM564260": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "77", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM56426": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "78", "MUTANT ALLELE": "Xu", "GENOTYPE/VARIATION": "Chrnb2-/- (verified by PCR from tail snip, parents are Xu mutant)"}}, {"GSM564262": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "748", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}, {"GSM564263": {"DEVELOPMENTAL STAGE": "Adult (after retinal ganglion cell segregation in lateral geniculate nucleus is complete)", "TISSUE": "left and right total retinas", "MOUSE": "763", "MUTANT ALLELE": "not specified", "GENOTYPE/VARIATION": "wild type"}}], "id": 6140, "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Mice lacking the beta 2 subunit (Chrnb2) of the neuronal nicotinic acetylcholine receptor display altered retinal waves and disorganized...", "geo_gse_id": "E-GEOD-22824", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 5, "sample_count": 24, "tags": ["acetylcholine", "acetylcholine receptor", "ganglion", "lateral", "nicotinic acetylcholine receptor", "retina"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-22824_A-AFFY-45", "slug": "gene-expression-in-retina-and-lgn-of-wild-type-and", "geo_gds_id": "", "name": "Gene expression in retina and LGN of wild type and Chrnb2-/- mice", "created": "Nov.11, 2014", "summary": "Mice lacking the beta 2 subunit (Chrnb2) of the neuronal nicotinic acetylcholine receptor display altered retinal waves and disorganized projections of the retinal ganglion cells to the lateral geniculate nucleus (LGN).  mRNA populations from retinas and LGN from Chrnb2-/-and wild type (C57BL/6J)  mice  were compared at 4 days postnatal, when RGC segregation to the LGN begins in WT mice.  Retinal mRNAs were also compared at adulthood. Using microarray hybridization, we identified transcripts which are differentially expressed between Chrnb2-/- and wild type animals in these two tissues at these two ages. mRNA was isolated from retina and LGN of three male littermates each of WT and Chrnb2-/- mice at P4.  mRNA from retinas of two adult male littermates of each type was also examined.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22824", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22824/samples/"}