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Home › Dataset Library › Expression data from G9a overexpression and knockdown lung cancer cell lines

Dataset: Expression data from G9a overexpression and knockdown lung cancer cell lines

G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regionsand is essential for murine embryogenesis . We...

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G9a is the major mammalian H3-K9 methyltransferase that targets euchromatic regionsand is essential for murine embryogenesis . We demonstrate that G9a is endowed with methyltransferase activity to concomitantly repress the downstream effector Ep-CAM, thereby promoting the invasion step of the invasion-metastasis cascade. We used microarrays to detail the G9a regulated gene expression underlying invasion-metastasis cascade and identified distinct classes of up-regulated genes during this process. Lung adenocarcinoma cells with G9a knockdown or overexpression were selected for RNA extraction and hybridization on Affymetrix microarrays.

Species:
human

Samples:
4

Source:
E-GEOD-22810

Updated:
Dec.12, 2014

Registered:
Sep.15, 2014


Factors: (via ArrayExpress)
Sample CELL LINE PROTOCOL
GSM563830 lung adenocarcinoma cell line CL1-5 control shRNA expression
GSM56383 lung adenocarcinoma cell line CL1-5 G9a knockdown
GSM563832 lung adenocarcinoma cell line CL1-0 control vector expression
GSM563833 lung adenocarcinoma cell line CL1-0 G9a overexpression

Tags

  • adenocarcinoma
  • lung
  • lung adenocarcinoma

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