ArrayExpress Uploader0humannot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified144mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified1510mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified9518mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified124fnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified383mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified383mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified1016mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified224mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified91mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified313mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified124mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified137mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified601mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified1566fnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified908fnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified908fnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified8>80mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified1142mnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified112fnot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specifiednot specified1275mnot specifiednot specifiedpT1bnot specifiedM0DFS = 106 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelymph node, bone, adrenal glandG2pT1bnot specifiedM1DFS = 0 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelung, liverG2pT1bnot specifiedM0DFS = 83 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalelung, soft tissueG2pT2not specifiedM0DFS = 6 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalelung, adrenal gland, renalG2pT2not specifiedM0DFS = 60 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemaleboneG2pT2not specifiedM0Follow-up = 155 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalenoneG2pT1anot specifiedM0DFS = 0 monthsN2not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelymph nodeG3pT2not specifiedM0Follow-up = 99 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalenoneG2pT2not specifiedM0DFS = 45 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalelung, bone, adrenal glandG2pT1bnot specifiedM0Follow-up = 112 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalenoneG3pT1anot specifiedM0DFS = 63 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalelungG3pT3bnot specifiedM0Follow-up = 143 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalenoneG2pT1anot specifiedM0DFS = 96 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelymph node, lungG2pT1anot specifiedM0Follow-up = 148 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalenoneG2pT1bnot specifiedM0DFS = 60 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmaleadrenal gland, renal, pancreas, parotisG2pT3bnot specifiedM1DFS = 0 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelung, mediastinalG3pT1bnot specifiedM0Follow-up = 130 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalenoneG3pT2not specifiedM0Follow-up = 140 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalenoneG2pT2not specifiedM0DFS = 1 monthN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemalelungG2pT2not specifiedM1DFS = 0 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedfemaleskinG2pT2not specifiedM1DFS = 0 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelungG2pT3anot specifiedM0DFS = 0 monthsN1not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelymph nodeG2pT3anot specifiedM0DFS = 82 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelung, skinG2pT3anot specifiedM0DFS = 90 monthsN0not specifiedprimary clear-cell renal cell carcinomanot specifiednot specifiedmalelungG3not specified44not specifiedDFS = 1 monthnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified10not specifiedDFS = 15 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified18not specifiedDFS = 95 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified4not specifiedDFS = 12 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specified3not specifiedDFS = 38 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified3not specifiedDFS = 38 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified16not specifiedDFS = 10 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified24not specifiedDFS = 2 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified1not specifiedDFS = 9 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified3not specifiedDFS = 31 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified24not specifiedDFS = 1 monthnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified37not specifiedDFS = 1 monthnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified1not specifiedDFS = 60 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified6not specifiedDFS = 156 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specified8not specifiedDFS = 90 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specified8not specifiedDFS = 90 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specified>80not specifiedDFS = 8 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified2not specifiedDFS = 114 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specified2not specifiedDFS = 11 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specified5not specifiedDFS = 127 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specifiednot specifiednot specifiedDFS = 2 monthsnot specifiedApr 2007pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedmalenot specifiednot specifiednot specifiednot specifiednot specifiedDFS = 36 monthsnot specifiedOct 2008pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specifiednot specifiednot specifiedDFS = 0 monthnot specifiedOct 2008pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specifiednot specifiednot specifiednot specifiedDFS = 0 monthnot specifiedOct 2008pulmonary metastasis of clear-cell renal cell carcinoma (laser resection)not specifiednot specifiedfemalenot specifiednot specified3715arrayexpress_sid4The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely...E-GEOD-22541/profile/8773/arrayexpressuploader1268carcinomacelldiseaseorganrenal cell carcinomaDec.12, 2014Falseexpression-data-from-pulmonary-metastases-and-primE-GEOD-22541_A-AFFY-44Expression data from pulmonary metastases and primary tumors of clear-cell renal cell carcinoma (ccRCC) with different disease-free survivalsSep.15, 2014The understanding of metastatic spread is limited and molecular mechanisms causing particular characteristics of metastasis are largely unknown. This comprises the extremely varying dormancy periods of tumor cells in the secondary organ after metastatic spread, represented by the disease-free survival (DFS) of the patients, or differing numbers of metastases in different patients. Knowing the molecular fundamentals of these phenomena would support the individual prediction of patients´ outcome and facilitate the decision for an appropriate monitoring and therapy regime. In a first study (PMID 19391132) we analyzed the transcriptome-wide expression profiles of 20 pulmonary metastases of renal cell carcinoma (Met1-9, Met11-18, Met20, Met23, Met25) to identify expression patterns associated with the dormancy period and the number of metastases per patient. Pre-processed and analyzed data for this study are available in GEO Series GSE14378. In this second study, we validated the DFS-associated expression pattern from the first study on four further metastases and also included primary ccRCC with different DFS. For this, the microarray data of all metastases and primary tumors were pre-processed together. The aim of this second study was to identify those genes, which are differentially expressed in metastases developed after different dormancy periods and which are already deregulated in primary tumors. Genes differentially expressed in synchronously vs. metachronously metastases might contribute functionally to the dormancy period. Genes already deregulated in primary ccRCC might be suitable for prognostic purposes. metastases manifested synchronously or metachronously (DFS less than or equal to 9 months compared with DFS greater than or equal to 60 months); primary ccRCC which developed synchronous or metachronous metastases (DFS less than or equal to 6 months compared with DFS greater than or equal to 45 months)http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22541http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22541/samples/