{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM555983": {"GNE MRNA": "unchanged"}}, {"GSM555983": {"GNE MRNA": "unchanged"}}, {"GSM555983": {"GNE MRNA": "unchanged"}}, {"GSM555986": {"GNE MRNA": "knock-down"}}, {"GSM555986": {"GNE MRNA": "knock-down"}}, {"GSM555986": {"GNE MRNA": "knock-down"}}], "id": 3698, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated...", "geo_gse_id": "E-GEOD-22336", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cancer", "pancreatic cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "udp-glcnac-2-epimerasemannac-kinase-gne-is-an-indu", "geo_id_plat": "E-GEOD-22336_A-AFFY-44", "name": "UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is an inducer of apoptotic processes in Capan-1 pancreatic carcinoma cells: GNE silencing", "created": "Sep.15, 2014", "summary": "Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated upon loss of adequate matrix anchorage. Re-expression of the tumor suppressor p16 reversed anoikis resistance of pancreatic cancer cells. This conversion to an anoikis-susceptible phenotype was found to be associated with a striking loss of GNE mRNA expression, prompting us to address the role of GNE in pancreatic cancer in more detail. GNE catalyzes a rate-limiting key step of the sialic acid biosynthesis and may have additional functions in the nucleus. Pancreatic cancer cells Capan-1. Three GNE-silencing samples and three control samples.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22336", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22336/samples/"}