{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM555975": {"P16 RESTORATION": "no"}}, {"GSM555975": {"P16 RESTORATION": "no"}}, {"GSM555975": {"P16 RESTORATION": "no"}}, {"GSM555978": {"P16 RESTORATION": "yes"}}, {"GSM555978": {"P16 RESTORATION": "yes"}}, {"GSM555978": {"P16 RESTORATION": "yes"}}], "id": 3697, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated...", "geo_gse_id": "E-GEOD-22334", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 6, "tags": ["cancer", "pancreatic cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-22334_A-AFFY-44", "slug": "induction-of-apoptotic-processes-in-capan-1-pancre", "geo_gds_id": "", "name": "Induction of apoptotic processes in Capan-1 pancreatic carcinoma cells by restoration of p16INK4a expression", "created": "Sep.15, 2014", "summary": "Early invasive growth and metastasis are features of pancreatic cancer that rely on resistance to anoikis, an apoptosis program activated upon loss of adequate matrix anchorage. Re-expression of the tumor suppressor p16 reversed anoikis resistance of pancreatic cancer cells. This conversion to an anoikis-susceptible phenotype was found to be associated with a striking loss of GNE mRNA expression, prompting us to address the role of GNE in pancreatic cancer in more detail. GNE catalyzes a rate-limiting key step of the sialic acid biosynthesis and may have additional functions in the nucleus. Pancreatic cancer cells Capan-1. Three p16-transfectants and three mock-transfectants.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22334", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22334/samples/"}