{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6123, "factors": [{"GSM55538": {"genotype": "wild type"}}, {"GSM55538": {"genotype": "wild type"}}, {"GSM55538": {"genotype": "wild type"}}, {"GSM55538": {"genotype": "wild type"}}, {"GSM555385": {"genotype": "B6.Sle1a.1"}}, {"GSM555385": {"genotype": "B6.Sle1a.1"}}, {"GSM555385": {"genotype": "B6.Sle1a.1"}}, {"GSM555385": {"genotype": "B6.Sle1a.1"}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as...", "pubmed_id": 22180614, "geo_gse_id": "E-GEOD-22313", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 8, "tags": ["cell", "lupus", "peripheral"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-mouse-cd4-t-ce", "geo_id_plat": "E-GEOD-22313_A-AFFY-45", "name": "Transcription profiling by array of mouse CD4+ T cells mutant for Sle1a.1", "created": "Nov.11, 2014", "summary": "Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as well as a reduction in the peripheral regulatory T cell (Treg) pool.  Sle1a.1 CD4+ T cells showed a defective response to retinoic acid (RA) expansion of TGF\u03b2-induced Tregs.  At the molecular level, Sle1a.1 corresponds to an increased expression of a novel splice isoform of Pbx1, Pbx1-d. Pbx1-d over-expression is sufficient to induce an activated/inflammatory phenotype in Jurkat T cells, and to decrease their apoptotic response to RA.  PBX1-d is expressed more frequently in lupus patients than in healthy controls, and its presence correlates with an increased memory T cell population.  These findings indicate that Pbx1 is a novel lupus susceptibility gene that regulates T cell activation and tolerance. Total RNA from CD4+ T cells from C57BL/6 (B6) and B6.Sle1a.1 (Sle) mice was isolated, with 4 biological replicates each. Gene expression data from C57BL/6 mice were compared with data from B6.Sle2c1 mice.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22313", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22313/samples/"}