{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "human", "factors": [{"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}, {"GSM547772": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: positive"}}, {"GSM547768": {"genotype": "estrogen receptor alpha mutation: positive; PIK3CA mutation: negative"}}], "id": 3670, "ownerprofile_id": "arrayexpress_sid", "platform": 4, "summary_wrapped": "PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the...", "pubmed_id": 21209903, "geo_gse_id": "E-GEOD-22035", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 43, "tags": ["breast", "breast cancer", "cancer"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-human-estrog-2", "geo_id_plat": "E-GEOD-22035_A-AFFY-44", "name": "Transcription profiling by array of human estrogen receptor alpha positive breast tumors with and without PIK3CA mutations.", "created": "Sep.15, 2014", "summary": "PI3K/AKT pathway plays one of pivotal roles in breast cancer development and maintenance. PIK3CA, coding PIK3 catalytic subunit, is the oncogene which shows the high frequency of gain-of-function mutations leading to the PI3K/AKT pathway activation in breast cancer. In particular in the ER\u03b1-positive breast tumors PIK3CA mutations have been observed in 30% to 40%. However, genes expressed in connection to the pathway activation in breast tumorigenesis remain largely unknown. To identify downstream relevant target genes (and signaling pathways) turned on by the aberrant PI3K/AKT signal in breast tumors, we analyzed gene expression by pangenomic oligonucleotide microarray in a series of 43 ER\u03b1-positive tumors with and without PIK3CA mutations. 43 ER\u03b1-positive breast tumors including 14 tumors with PIK3CA mutations and 29 tumors without PIK3CA mutattions were used as screening set for microarray.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22035", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-22035/samples/"}