{"owner": "ArrayExpress Uploader", "ownerprofile_id": "arrayexpress_sid", "id": 6083, "factors": [{"GSM54347": {"TREATMENT": "Media + DMSO"}}, {"GSM543472": {"TREATMENT": "Fraction"}}, {"GSM543473": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin)"}}, {"GSM543474": {"TREATMENT": "Media + DMSO + LPS"}}, {"GSM543475": {"TREATMENT": "Fraction + LPS"}}, {"GSM543476": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin) + LPS"}}, {"GSM54347": {"TREATMENT": "Media + DMSO"}}, {"GSM543472": {"TREATMENT": "Fraction"}}, {"GSM543473": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin)"}}, {"GSM543474": {"TREATMENT": "Media + DMSO + LPS"}}, {"GSM543475": {"TREATMENT": "Fraction + LPS"}}, {"GSM543476": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin) + LPS"}}, {"GSM54347": {"TREATMENT": "Media + DMSO"}}, {"GSM543472": {"TREATMENT": "Fraction"}}, {"GSM543473": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin)"}}, {"GSM543474": {"TREATMENT": "Media + DMSO + LPS"}}, {"GSM543475": {"TREATMENT": "Fraction + LPS"}}, {"GSM543476": {"TREATMENT": "4CS (0.07 uM amentoflavone, 0.08 uM quercetin, 0.2 uM chlorogenic acid, and 0.03 uM pseudohypericin) + LPS"}}], "pop_total": 0, "platform": 6, "summary_wrapped": "Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and...", "pubmed_id": 20303133, "geo_gse_id": "E-GEOD-21841", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 1, "sample_count": 18, "tags": [], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "expression-data-from-lps-stimulated-raw-2647-mouse", "geo_id_plat": "E-GEOD-21841_A-AFFY-45", "name": "Expression data from LPS-stimulated RAW 264.7 mouse macrophages treated with Hypericum perforatum fraction and bioactive constituents", "created": "Nov.11, 2014", "summary": "Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflammatory activity of the identified compounds, we used Affymatrix microarray to study the gene expression profile impacteded by these compounds, as well as the active fraction in LPS-stimulated mouse macrophages. We treated RAW264.7 mouse macrophages with DMSO control, active fraction from Hypericum perforaum extract, and a combination of the 4 putative bioactive compounds, called the 4-component system, all with and without LPS induction. A total of six treatment combinations were included in the final gene expression analysis using microarray.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-21841", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-21841/samples/"}