{"owner": "ArrayExpress Uploader", "pop_total": 0, "species": "mouse", "factors": [{"GSM540647": {"TREATMENT": "withdrawal of IL-7", "GENOTYPE": "none"}}, {"GSM540647": {"TREATMENT": "withdrawal of IL-7", "GENOTYPE": "none"}}, {"GSM540647": {"TREATMENT": "withdrawal of IL-7", "GENOTYPE": "none"}}, {"GSM540650": {"TREATMENT": "none", "GENOTYPE": "none"}}, {"GSM540650": {"TREATMENT": "none", "GENOTYPE": "none"}}, {"GSM540650": {"TREATMENT": "none", "GENOTYPE": "none"}}, {"GSM540653": {"TREATMENT": "none", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540653": {"TREATMENT": "none", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540653": {"TREATMENT": "none", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540680": {"TREATMENT": "STI571 in absence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540680": {"TREATMENT": "STI571 in absence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540680": {"TREATMENT": "STI571 in absence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540683": {"TREATMENT": "STI571 in presence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540683": {"TREATMENT": "STI571 in presence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}, {"GSM540683": {"TREATMENT": "STI571 in presence of IL-7", "GENOTYPE": "BCR-ABL1-transformation"}}], "id": 8473, "ownerprofile_id": "arrayexpress_sid", "platform": 8, "summary_wrapped": "This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress...", "pubmed_id": 20498019, "geo_gse_id": "E-GEOD-21664", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 15, "tags": ["cell", "immunoglobulin", "interleukin", "interleukin-7"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_id_plat": "E-GEOD-21664_A-AFFY-36", "slug": "transcription-profiling-by-array-of-interleukin-7", "geo_gds_id": "", "name": "Transcription profiling by array of interleukin-7-dependent and BCR-ABL1-transformed Mus musculus pre-B cells", "created": "Nov.24, 2014", "summary": "This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including  immunoglobulin light chain gene recombination were performed by withdrawal of interleukin-7 (IL-7) from IL-7-dependent murine pre-B cells or by inhibition of the BCR-ABL1 kinase activity in BCR-ABL1-transformed pre-B cells. The BCR-ABL1 kinase inhibitor STI571 (Imatinib) was used for the inhibition of BCR-ABL1. IL-7-dependent murine pre-B cells were either cultured in IL-7 (10 ng/ml) or induced to differentiate by withdrawal of IL-7. BCR-ABL1-transformed pre-B cells were either treated with 10 \u00b5M STI571 (in absence or presence of 10 ng/ml IL-7) for 16 hours or cultured without STI571. Three samples for each condition were processed.", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-21664", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-21664/samples/"}