{"owner": "ArrayExpress Uploader", "pop_total": 0, "id": 6002, "factors": [{"GSM517944": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517944": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517944": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517947": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517947": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517947": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517947": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517947": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517952": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517952": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517952": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517952": {"GENOTYPE": "Villin-CRE+ (PPAR g null epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517956": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517956": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517956": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 0}}, {"GSM517959": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517959": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517959": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 2}}, {"GSM517962": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517962": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517962": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 7}}, {"GSM517962": {"GENOTYPE": "Villin-CRE- (Wild-type epithelial cell)", "TREATMENT DURATION": 7}}], "ownerprofile_id": "arrayexpress_sid", "platform": 6, "summary_wrapped": "BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate...", "pubmed_id": 20422041, "geo_gse_id": "E-GEOD-20621", "owner_profile": "/profile/8773/arrayexpressuploader", "factor_count": 2, "sample_count": 22, "tags": ["body", "cell", "colitis", "colon", "disease", "dss", "epithelial cell", "lymph", "macrophage", "mucosa", "peroxisome"], "lastmodified": "Dec.12, 2014", "is_default": false, "geo_gds_id": "", "slug": "transcription-profiling-by-array-of-mus-musculus-c", "geo_id_plat": "E-GEOD-20621_A-AFFY-45", "name": "Transcription profiling by array of Mus musculus colonic mucosa after treatment with DSS", "created": "Nov.11, 2014", "summary": "BACKGROUND: Peroxisome proliferator-activated receptor g (PPAR g) is a nuclear receptor whose activation has been shown to modulate macrophage and epithelial cell-mediated inflammation.  The objective of this study was to use a systems approach for investigating the mechanism by which the deletion of PPAR g in epithelial cells modulates the severity of dextran-sodium sulfate (DSS)-induced colitis, immune cell distribution and global gene expression. RESULTS: The deficiency of PPAR g in epithelial cells does not significantly affect disease activity or body weight but worsens colon histopathlogy. WT mice have greater CD4+IL10+ T cells and fewer MHC II+ macrophages in mesenteric lymph nodes. Global gene expression analysis reveals greater changes after 7 days of DSS challenge (compared to 2 days). Colonic mucosa from VC- (WT) and VC+ (PPARg knock-out in epithelial cells) mice were sampled at 0 (no DSS), 2, and 7 days of DSS-induced experimental colitis", "source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20621", "species": "mouse", "sample_source": "http://www.ebi.ac.uk/arrayexpress/experiments/E-GEOD-20621/samples/"}